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Titolo:
The treatment of oral aphthous ulceration or erosive lichen planus with topical clobetasol propionate in three preparations: a clinical and pilot study on 54 patients
Autore:
Muzio, LL; della Valle, A; Mignogna, MD; Pannone, G; Bucci, P; Bucci, E; Sciubba, J;
Indirizzi:
Univ Ancona, Inst Dent Sci, Ancona, Italy Univ Ancona Ancona ItalyUniv Ancona, Inst Dent Sci, Ancona, Italy Univ Naples Federico II, Div Oral Pathol & Med, Naples, Italy Univ Naples Federico II Naples Italy v Oral Pathol & Med, Naples, Italy Long Isl Jewish Med Ctr, Dept Dent Med, New Hyde Pk, NY 11042 USA Long IslJewish Med Ctr New Hyde Pk NY USA 11042 ew Hyde Pk, NY 11042 USA
Titolo Testata:
JOURNAL OF ORAL PATHOLOGY & MEDICINE
fascicolo: 10, volume: 30, anno: 2001,
pagine: 611 - 617
SICI:
0904-2512(200111)30:10<611:TTOOAU>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESICULOEROSIVE DISEASES; APPLIED FLUOCINONIDE; ADRENAL SUPPRESSION; ADHESIVE BASE; STOMATITIS; MANAGEMENT; TRIAL; CORTICOSTEROIDS; ASSOCIATION; PREDNISONE;
Keywords:
adhesive paste; clobetasol propionate; vesiculo-ulcero-erosive oral lesions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Muzio, LL Via Carelli 28, I-71100 Foggia, Italy Via Carelli 28 Foggia Italy I-71100 28, I-71100 Foggia, Italy
Citazione:
L.L. Muzio et al., "The treatment of oral aphthous ulceration or erosive lichen planus with topical clobetasol propionate in three preparations: a clinical and pilot study on 54 patients", J ORAL PATH, 30(10), 2001, pp. 611-617

Abstract

Background: This study evaluated the clinical use of a cortico steroid in three preparations (topical clobetasol propionate ointment, clobetasol propionate in an oral analgesic base, and clobetasol propionate in an adhesive denture paste). Methods: Fifty-four patients (34 males and 20 females) with a history of vesiculo-ulcero-erosive oral lesions were selected: 24 with oral erosive lichen planus and 30 with aphthae. The subjects enrolled were randomly dividedinto three groups, each of 18 patients (10 with aphthae and 8 with lichen planus): the first was treated with topical clobetasol propionate ointment (0.05%) directly on the lesion(s) three times a day; the second with clobetasol propionate in an adhesive denture paste in equal amounts (1:1) two times a day; the third with clobetasol propionate in an oral analgesic base (Orabase-B) in equal amounts (1:1) two times a day. Each subject scored his or her symptoms daily from most severe (7) to none (0) by verbal assessmentsusing a categorical scale. Results: In all cases, the administration of the corticosteroid was effective in producing remission of symptoms in each group of patients. Significant differences (P <0.05) between groups were determined by the Kruskal-Wallis test. The Dunn test was used in order to detect which group differs fromthe others; clobetasol and adhesive denture paste correlated with an earlyremission of pain in lichen and apthous lesions. Conclusion: The results suggest that topical application of clobetasol in an adhesive denture paste is an effective drug for symptomatic oral vesiculo-erosive and/or ulcerative lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:24:03