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Titolo:
CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes
Autore:
Nakagaki, K; Nakagaki, K; Takahashi, K; Schols, D; De Clercq, E; Tabira, T;
Indirizzi:
Natl Inst Neurosci, NCNP, Kodaira, Tokyo, Japan Natl Inst Neurosci Kodaira Tokyo Japan osci, NCNP, Kodaira, Tokyo, Japan Nippon Jui Chikusan Univ, Musashino, Tokyo, Japan Nippon Jui Chikusan Univ Musashino Tokyo Japan , Musashino, Tokyo, Japan Rega Inst, Louvain, Belgium Rega Inst Louvain BelgiumRega Inst, Louvain, Belgium
Titolo Testata:
JOURNAL OF NEUROVIROLOGY
fascicolo: 5, volume: 7, anno: 2001,
pagine: 487 - 492
SICI:
1355-0284(200110)7:5<487:CITPRF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DERIVED FACTOR; NECROSIS-FACTOR-ALPHA; MICROGLIAL CELLS; SELECTIVE-INHIBITION; HIV-1 INFECTION; BRAIN CULTURES; SHARED USAGE; GLIAL-CELLS; TYPE-1; REPLICATION;
Keywords:
FIV; chemokine receptor; AMD3100; astrocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Tabira, T Natl Inst Longev Sci, 36-3 Gengo,Morioka Cho, Aichi 4748522, Japan Natl Inst Longev Sci 36-3 Gengo,Morioka Cho Aichi Japan 4748522
Citazione:
K. Nakagaki et al., "CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes", J NEUROVIRO, 7(5), 2001, pp. 487-492

Abstract

Feline astrocytes were productively infected with the Crandell feline kidney (CrFK) cell-adapted feline immunodeficiency virus (FIV) Petaluma strain in a primary culture. They expressed mRNA of CXCR4, and the FIV infection was blocked by stromal cell-derived factor 1 alpha (SDF-1 alpha), SDF-1 beta, or the bicyclam AMD3100 in a dose-dependent manner. These observations suggest that, like FIV infection in CrFK cells and lymphocytes, the virus uses CXCR4 as a primary receptor for infecting astrocytes and this can be a possible natural model for AIDS dementia complex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:27:13