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Titolo:
Diazepam inhibits HIV-1 Tat-induced migration of human microglia
Autore:
Lokensgard, JR; Hu, SX; Hegg, CC; Thayer, SA; Gekker, G; Peterson, PK;
Indirizzi:
Minneapolis Med Res Fdn Inc, Neuroimmunol Lab, Minneapolis, MN 55404 USA Minneapolis Med Res Fdn Inc Minneapolis MN USA 55404 apolis, MN 55404 USA Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 pt Med, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 rmacol, Minneapolis, MN 55455 USA
Titolo Testata:
JOURNAL OF NEUROVIROLOGY
fascicolo: 5, volume: 7, anno: 2001,
pagine: 481 - 486
SICI:
1355-0284(200110)7:5<481:DIHTMO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTOR LIGANDS; CENTRAL-NERVOUS-SYSTEM; TUMOR-NECROSIS-FACTOR; RAT-BRAIN; CHEMOTAXIS; PROTEIN; CELLS; CHEMOKINES; EXPRESSION; APOPTOSIS;
Keywords:
diazepam; HIV-1; microglia; Tat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lokensgard, JR Minneapolis Med Res Fdn Inc, Neuroimmunol Lab, 914 S 8th St,Bldg D-3, Minneapolis, MN 55404 USA Minneapolis Med Res Fdn Inc 914 S 8th St,Bldg D-3 Minneapolis MN USA 55404
Citazione:
J.R. Lokensgard et al., "Diazepam inhibits HIV-1 Tat-induced migration of human microglia", J NEUROVIRO, 7(5), 2001, pp. 481-486

Abstract

During HIV-1 encephalitis, the chemotaxis-inducing activity of Tat may enhance the viral life cycle through recruitment of additional susceptible microglial cells to foci of infection. Benzodiazepines (BDZs) readily penetrate the blood-brain barrier and are known to possess anti-inflammatory properties. Pretreatment of human microglial cells with peripheral (Ro5-4864) andmixed (diazepam), but not central (clonazepam), benzodiazepine receptor ligands was found to potently suppress HIV-1 Tat-induced chemotaxis. Application of Tat to microglial cells evokes an increase in intracellular calcium concentration ([Ca2+](i)) that rapidly desensitizes the cells. Diazepam's inhibitory effect was associated with its ability to block Tat-induced [Ca2+](i) mobilization. These data support the notion that through their effectson microglia, peripheral BDZ receptor ligands could alter the neuropathogenesis of HIV-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:04:56