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Titolo:
Autonomous nervous system innervation of lymphoid territories in spleen: Apossible involvement of noradrenergic neurons for prion neuroinvasion in natural scrapie
Autore:
Bencsik, A; Lezmi, S; Baron, T;
Indirizzi:
Agence Francaise Securite Sanitaire Aliments, Unite Virol, ATNC, F-69364 Lyon 07, France Agence Francaise Securite Sanitaire Aliments Lyon France 07 n 07, France
Titolo Testata:
JOURNAL OF NEUROVIROLOGY
fascicolo: 5, volume: 7, anno: 2001,
pagine: 447 - 453
SICI:
1355-0284(200110)7:5<447:ANSIOL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUFFOLK SHEEP; MOUSE SCRAPIE; IMMUNE-SYSTEM; PRP GENOTYPE; CLOSED FLOCK; PROTEIN; PATHOGENESIS; INFECTION; SPREAD; AGENT;
Keywords:
noradrenaline; neuroinvasion; PrP; scrapie; tyrosine hydroxylase; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Bencsik, A Agence Francaise Securite Sanitaire Aliments, Unite Virol, ATNC, 31 Ave Tony Garnier, F-69364 Lyon 07, France Agence Francaise Securite Sanitaire Aliments 31 Ave Tony Garnier Lyon France 07
Citazione:
A. Bencsik et al., "Autonomous nervous system innervation of lymphoid territories in spleen: Apossible involvement of noradrenergic neurons for prion neuroinvasion in natural scrapie", J NEUROVIRO, 7(5), 2001, pp. 447-453

Abstract

In experimental as well as in natural scrapie, transmissible spongiform encephalopathies (TSEs), the infectious agent, closely related to PrPsc, an abnormal isoform of the cellular prion protein, invades and replicates in lymphoid organs such as spleen before affecting the brain. To clarify the cellular requirements for the possible neuroinvasion of scrapie agent from thespleen to the central nervous system, we have studied the sympathetic innervation within the lymphoid territories of the spleen. These noradrenergic fibers originating from the coeliomesenteric ganglia were examined with regard to PrPsc-associated cells in spleen of adult sheep severely affected with natural scrapie. Using a double immunolabelling strategy, we demonstrated the proximity of noradrenergic endings with PrPsc-accumulating cells, strengthening its possible implication in the neuroinvasion process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:15:26