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Titolo:
Sequence analysis of the S gene of recombinant MHV-2/A59 coronaviruses reveals three candidate mutations associated with demyelination and hepatitis
Autore:
Das Sarma, J; Fu, L; Hingley, ST; Lai, MMC; Lavi, E;
Indirizzi:
Univ Penn, Sch Med, Dept Pathol & Lab Med, Div Neuropathol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 uropathol, Philadelphia, PA 19104 USA Philadelphia Coll Osteopath Med, Dept Microbiol & Immunol, Philadelphia, PA USA Philadelphia Coll Osteopath Med Philadelphia PA USA Philadelphia, PA USA Univ So Calif, Sch Med, Howard Hughes Med Inst, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Immunol, Los Angeles, CA 90033 USA
Titolo Testata:
JOURNAL OF NEUROVIROLOGY
fascicolo: 5, volume: 7, anno: 2001,
pagine: 432 - 436
SICI:
1355-0284(200110)7:5<432:SAOTSG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE CORONAVIRUS; TARGETED RECOMBINATION; SPIKE GLYCOPROTEIN; VIRUS; PATHOGENESIS; PROTEIN; FUSION; SITE; MICE; DETERMINANTS;
Keywords:
coronavirus; nidoviruses; mouse hepatitis virus (MHN); demyelination; hepatitis; multiple sclerosis (MS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Lavi, E Univ Penn, Sch Med, Dept Pathol & Lab Med, Div Neuropathol, 613 Stellar Chance Labs,422 Curie Blvd, Philadelphia, PA 19104 USA Univ Penn 613 Stellar Chance Labs,422 Curie Blvd Philadelphia PA USA 19104
Citazione:
J. Das Sarma et al., "Sequence analysis of the S gene of recombinant MHV-2/A59 coronaviruses reveals three candidate mutations associated with demyelination and hepatitis", J NEUROVIRO, 7(5), 2001, pp. 432-436

Abstract

Coronaviruses, mouse hepatitis virus (MHV) strains, exhibit various degrees of neurotropism and hepatotropism following intracerebral (IC) infection of 4-week-old C57Bl/6 mice. Whereas MHV-A59 produces acute meningitis, encephalitis, hepatitis, and chronic demyelination, a closely related strain, MHV-2, produces only acute meningitis and hepatitis. We previously reported that the spike glycoprotein gene of MHV contains determinants of demyelination and hepatitis. To further investigate the site of demyelination and hepatitis determinants within the S gene, we sequenced the S gene of several nondemyelinating recombinant viruses. We found that three encephalitis-positive, demyelination-negative, hepatitis-negative recombinant viruses have anMHV-A59-derived S gene, which contains three identical point mutations (I375M, L6521, and T1087N). One or more of the sites of these mutations in theMHV-A59 genome are likely to contribute to demyelination and hepatitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:47:04