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Titolo:
Intraoperative values of S-100 protein, myelin basic protein, lactate, andalbumin in the CSF and serum of neurosurgical patients
Autore:
de Vries, J; Thijssen, WAMH; Snels, SEA; Menovsky, T; Peer, NGM; Lamers, KJB;
Indirizzi:
Univ Nijmegen Hosp, Dept Neurosurg, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp Nijmegen Netherlands NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp, Dept Neurol, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp Nijmegen Netherlands NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp, Dept Med Stat, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp Nijmegen Netherlands NL-6500 HB Nijmegen, Netherlands
Titolo Testata:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
fascicolo: 5, volume: 71, anno: 2001,
pagine: 671 - 674
SICI:
0022-3050(200111)71:5<671:IVOSPM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURON-SPECIFIC ENOLASE; CENTRAL NERVOUS-SYSTEM; CEREBROSPINAL-FLUID; HEAD-INJURY; PREDICTION; DAMAGE; EDEMA;
Keywords:
S-100; myelin basic protein; neurosurgery; cerebrospinal fluid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: de Vries, J Univ Nijmegen Hosp, Dept Neurosurg, POB 9101, NL-6500 HB Nijmegen, Netherlands Univ Nijmegen Hosp POB 9101 Nijmegen Netherlands NL-6500 HB s
Citazione:
J. de Vries et al., "Intraoperative values of S-100 protein, myelin basic protein, lactate, andalbumin in the CSF and serum of neurosurgical patients", J NE NE PSY, 71(5), 2001, pp. 671-674

Abstract

Objectives-To assess the concentrations of S-100 protein, myelin basic protein (MBP), and lactate, and the (CSF)/serum albumin ratio (Qalb) during intracranial neurosurgical procedures. Methods-Samples of CSF from 91 patients with various CNS diseases were obtained by aspiration of cisternal CSF at the beginning of surgery (before starting surgical manipulation of the brain) and concentrations of S-100 protein, MBP, and lactate, and Qalb were determined. At the same time blood wassampled for determination of serum S-100 protein concentration. Patients were divided into three groups according to the aetiology of their CNS disease (intracranial haemorrhage, n=11; benign intracranial mass lesion, n=52; malignant neoplastic disease, n=28). Radiological and intraoperative characteristics were documented. Results-in each of these three groups median values of all four CSF variables measured were raised. The occurrence of brain oedema and a midline shift correlated significantly with raised concentrations of MBP and Qa1b. Breaching of the arachnoid layer, documented at surgery for benign lesions, correlated with higher concentrations of MBP, lactate, CSF S-100 protein, and Qa1b. Conclusions-Intraoperative values of S-100 protein, MBP, lactate, and Qa1bare increased in patients with intracranial haemorrhage, benign intracranial mass lesion, and malignant neoplastic disease. Breaching of the arachnoid layer and oedema is associated with higher concentrations of some of the aforementioned proteins. These biochemical data can serve as a basis for further research into CSF specific proteins.

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Documento generato il 29/03/20 alle ore 09:24:32