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Titolo:
Loss of CD95 expression is linked to most but not all p53 mutants in European hepatocellular carcinoma
Autore:
Volkmann, M; Schiff, JH; Hajjar, Y; Otto, G; Stilgenbauer, F; Fiehn, W; Galle, PR; Hofmann, WJ;
Indirizzi:
Univ Heidelberg, Med Klin & Poliklin, Zentrallab, D-69115 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69115 , D-69115 Heidelberg, Germany Univ Heidelberg, Anasthesiol Klin, Heidelberg, Germany Univ Heidelberg Heidelberg Germany nasthesiol Klin, Heidelberg, Germany Univ Mainz, Zentrum Transplanatsioschirurg, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 planatsioschirurg, D-6500 Mainz, Germany Univ Mainz, Med Klin 1, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 Mainz, Med Klin 1, D-6500 Mainz, Germany Univ Heidelberg, Inst Pathol, D-6900 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-6900 ol, D-6900 Heidelberg, Germany
Titolo Testata:
JOURNAL OF MOLECULAR MEDICINE-JMM
fascicolo: 10, volume: 79, anno: 2001,
pagine: 594 - 600
SICI:
0946-2716(200110)79:10<594:LOCEIL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POINT MUTATIONS; HEPATOMA-CELLS; APOPTOSIS; LIGAND; SSCP; FAS; SUPPRESSION; RECEPTOR; ANTIGEN; TISSUES;
Keywords:
apoptosis; Apo1/fas; hepatocellular carcinoma; liver; carcinogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Volkmann, M Univ Heidelberg, Med Klin & Poliklin, Zentrallab, Bergheimer Str 58, D-69115 Heidelberg, Germany Univ Heidelberg Bergheimer Str 58 Heidelberg Germany D-69115
Citazione:
M. Volkmann et al., "Loss of CD95 expression is linked to most but not all p53 mutants in European hepatocellular carcinoma", J MOL MED-J, 79(10), 2001, pp. 594-600

Abstract

Experimental data have shown p53-dependent CD95 induction to be associatedwith increased levels of apoptosis after cytostatic treatment in hepatoma cells. A study of Japanese hepatocellular carcinoma (HCC) has reported an inverse correlation between CD95 and p53 expression. To examine the interaction of p53 and CD95 in tumors we investigated which alterations in p53 can be linked to loss of CD95 expression in European HCC. In 39 tumors we analyzed CD95 by immunohistochemistry and assessed the correlation between the findings of the p53 status as determined by immunohistochemistry and single-strand conformation polymorphism with polymerase chain reaction sequencing. In 10 of 14 tumors with evidence of p53 aberration there was also loss of CD95 expression, compared to 6 of 25 samples with apparent wild-type p53 (P< 0.01). Three tumors with p53 mutations but sustained CD95 expression showed single base substitutions mapping to a narrow region of 20 codons in p53. A significant correlation with differentiation status of the tumor was found for the p53 aberration but not for CD95 expression. This is the first study to link loss of CD95 expression to specific p53 alterations in HCC. Functional p53 appears to be a major factor for CD95 expression in hepatocytes, the loss of which could contribute to chemoresistance and possibly immune evasion in hepatocellular carcinoma. Sustained CD95 expression in tumorswith certain p53 aberrations may indicate functional heterogeneity of p53 mutants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:19:55