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Titolo:
Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant
Autore:
Strazzullo, P; Iacone, R; Siani, A; Barba, G; Russo, O; Russo, P; Barbato, A; DElia, L; Farinaro, E; Cappuccio, FP;
Indirizzi:
Univ Naples Federico II, Sch Med, Dept Clin & Expt Med, Unit Clin Genet & Pharmacol, I-80131 Naples, Italy Univ Naples Federico II Naples Italy I-80131 acol, I-80131 Naples, Italy Inst Food Sci & Technol, CNR, Avellino, Italy Inst Food Sci & Technol Avellino Italy & Technol, CNR, Avellino, Italy Univ Naples Federico II, Dept Prevent Med Sci, I-80131 Naples, Italy Univ Naples Federico II Naples Italy I-80131 Sci, I-80131 Naples, Italy Univ London St Georges Hosp, Sch Med, Dept Gen Practice & Primary Care, London SW17 0RE, England Univ London St Georges Hosp London England SW17 0RE on SW17 0RE, England
Titolo Testata:
JOURNAL OF MOLECULAR MEDICINE-JMM
fascicolo: 10, volume: 79, anno: 2001,
pagine: 574 - 580
SICI:
0946-2716(200110)79:10<574:ARSHAH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; URIC-ACID EXCRETION; BLOOD-PRESSURE; LITHIUM CLEARANCE; MISSENSE MUTATION; PROXIMAL TUBULE; CYCLIC-AMP; KIDNEY; POPULATION; INSULIN;
Keywords:
blood pressure; hypertension; glucagon; cAMP; natriuresis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Strazzullo, P Univ Naples Federico II, Sch Med, Dept Clin & Expt Med, UnitClin Genet & Pharmacol, Via S Pansini 5, I-80131 Naples, Italy Univ NaplesFederico II Via S Pansini 5 Naples Italy I-80131
Citazione:
P. Strazzullo et al., "Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant", J MOL MED-J, 79(10), 2001, pp. 574-580

Abstract

A higher prevalence of hypertension has been associated with the G -->A/GT(Gly40Ser) polymorphism of the glucagon receptor gene (GCGR) in two population studies. As the mutated receptor is less responsive to glucagon, it has been speculated that the increased susceptibility to hypertension is due to deprivation of the recognized natriuretic effect of the hormone. To testthis hypothesis we determined the frequency of the polymorphic variant andevaluated the segmental renal sodium handling by the clearances of uric acid and of exogenous lithium in the Olivetti Heart Study participants (n = 971). The polymorphic variant was present only in heterozygous form in 37 individuals (3.8%). After controlling for age and body mass index, the carriers of the variant were twice more likely to be hypertensive and almost three times more likely to be on antihypertensive treatment at the time of examination. Compared to participants carrying the wild type, those carrying the Gly40Ser allele had higher serum uric acid and lower fractional excretionof uric acid and exogenous lithium, independently of age, body mass, and current pharmacological treatment. We conclude that the Gly40Ser polymorphism of the GCGR gene is associated with higher risk of hypertension and with enhanced proximal tubular sodium reabsorption, a factor possibly contributing to hypertension in this group.

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Documento generato il 04/12/20 alle ore 13:00:54