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Titolo:
Identifications, classification, and evolution of the vertebrate alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit genes
Autore:
Chen, YC; Kung, SS; Chen, BY; Hung, CC; Chen, CC; Wang, TY; Wu, YM; Lin, WH; Tzeng, CS; Chow, WY;
Indirizzi:
Natl Tsing Hua Univ, Dept Life Sci, Hsinchu 30043, Taiwan Natl Tsing Hua Univ Hsinchu Taiwan 30043 Life Sci, Hsinchu 30043, Taiwan
Titolo Testata:
JOURNAL OF MOLECULAR EVOLUTION
fascicolo: 6, volume: 53, anno: 2001,
pagine: 690 - 702
SICI:
0022-2844(200112)53:6<690:ICAEOT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE-OPERATED CHANNELS; GLUR-B; GENOME DUPLICATIONS; CHORDATE EVOLUTION; MOLECULAR-CLONING; CDNA MOLECULES; Q/R SITE; DIVERGENCE; FISH; ORGANIZATION;
Keywords:
vertebrate; teleost; AMPA receptor subunit; RT-PCR; gene duplication;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Chow, WY Natl Tsing Hua Univ, Dept Life Sci, 101,Sec 2,Kang Fu Rd, Hsinchu30043, Taiwan Natl Tsing Hua Univ 101,Sec 2,Kang Fu Rd Hsinchu Taiwan 30043 an
Citazione:
Y.C. Chen et al., "Identifications, classification, and evolution of the vertebrate alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit genes", J MOL EVOL, 53(6), 2001, pp. 690-702

Abstract

The AMPA receptor (AMPAR), a pharmacologically defined ionotropic glutamate receptor, mediates fast excitatory synaptic transmission in the vertebrate central nervous system. Mammalian and avian AMPARs are assembled from theproducts of four genes (GRIA1-GRIA4) conserved in their translated sequences and gene organizations. Teleost fish also express AMPAR subunits; however, the AMPAR genes have not been extensively investigated in lower vertebrates. To elucidate the evolution of vertebrate AMPAR genes, reverse-transcriptase, PCR-based surveys of subunits expressed in the brains of eight non-mammalian vertebrates were performed. The newly cloned vertebrate AMPAR subunits were classified by their sequence identities to the mammalian AMPAR subunits. The results of molecular and phylogenetic analyses indicated that the members of the AMPAR gene family increased from two in the jawless hagfish to four in the tetrapods and the shark and to more than four in the teleost fish. The sizes of AMPAR gene families correlate well with those of many multigene families observed in various vertebrates. Moreover, all vertebrates expressed at least one AMPAR subunit bearing an arginine (R) at the Q/R site, at which no invertebrate glutamate receptor subunit has been found to have an R residue, suggesting that the low calcium-permeable AMPARs appeared at early evolutionary stages of vertebrate central nervous systems. Uniquely, the loop 1 (L1) regions between hydrophobic domain 1 and hydrophobic domain 2 of the hagfish putative GRIA2 and all the teleost GRIA1 subunitswere much longer than those of the remaining known ionotropic glutamate receptor subunits. The length and sequence of the L1 of teleost GRIA1 subunits were heterogeneous, suggesting that the amino acid residues in L1 were not highly selected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:59:13