Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
N-succinyl-(beta-alanyl-L-leucyl-L-alanyl-L-leucyl)doxorubicin: An extracellularly tumor-activated prodrug devoid of intravenous acute toxicity
Autore:
Fernandez, AM; Van Derpoorten, K; Dasnois, L; Lebtahi, K; Dubois, V; Lobl, TJ; Gangwar, S; Oliyai, C; Lewis, ER; Shochat, D; Trouet, A;
Indirizzi:
Univ Catholique Louvain, Cell Biol Lab, B-1348 Louvain, Belgium Univ Catholique Louvain Louvain Belgium B-1348 , B-1348 Louvain, Belgium Corixa Corp, S San Francisco, CA 94080 USA Corixa Corp S San Francisco CAUSA 94080 p, S San Francisco, CA 94080 USA
Titolo Testata:
JOURNAL OF MEDICINAL CHEMISTRY
fascicolo: 22, volume: 44, anno: 2001,
pagine: 3750 - 3753
SICI:
0022-2623(20011025)44:22<3750:NAE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELF-ASSOCIATION; DOXORUBICIN; DERIVATIVES; PROTAMINE; PLASMIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Fernandez, AM Univ Catholique Louvain, Cell Biol Lab, Pl Croix Sud 5, B-1348 Louvain, Belgium Univ Catholique Louvain Pl Croix Sud 5 Louvain BelgiumB-1348
Citazione:
A.M. Fernandez et al., "N-succinyl-(beta-alanyl-L-leucyl-L-alanyl-L-leucyl)doxorubicin: An extracellularly tumor-activated prodrug devoid of intravenous acute toxicity", J MED CHEM, 44(22), 2001, pp. 3750-3753

Abstract

Intravenous administration of N-(beta -alanyl-L-leucyl-L-alanyl-L-leucyl)doxorubicin (4) induces an acute toxic reaction, killing animals in a few minutes. This results from its positive charge at physiological pH combined with its propensity to form large aggregates in aqueous solutions. Negatively charged N-capped versions of 4 such as the succinyl derivative 5 can be administered by the iv route at more than 10 times the LD50 of doxorubicin without inducing the acute toxic reaction, and they are active in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:12:27