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Titolo:
Rapid enantiomeric quantification of an antiviral nucleoside agent (D,L-FMAU, 2 '-fluoro-5-methyl-beta,D,L-arabinofurano-syluracil) by mass spectrometry
Autore:
Tao, WA; Wu, LM; Cooks, RG; Wang, F; Begley, JA; Lampert, B;
Indirizzi:
Purdue Univ, Dept Chem, W Lafayette, IN 47906 USA Purdue Univ W LafayetteIN USA 47906 Dept Chem, W Lafayette, IN 47906 USA Triangle Pharmaceut Inc, Durham, NC 27707 USA Triangle Pharmaceut Inc Durham NC USA 27707 eut Inc, Durham, NC 27707 USA
Titolo Testata:
JOURNAL OF MEDICINAL CHEMISTRY
fascicolo: 22, volume: 44, anno: 2001,
pagine: 3541 - 3544
SICI:
0022-2623(20011025)44:22<3541:REQOAA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
D,L-AMINO ACIDS; KINETIC METHOD; GAS-PHASE; THERMOCHEMICAL DETERMINATIONS; COMPLEXES;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Cooks, RG Purdue Univ, Dept Chem, W Lafayette, IN 47906 USA Purdue Univ WLafayette IN USA 47906 W Lafayette, IN 47906 USA
Citazione:
W.A. Tao et al., "Rapid enantiomeric quantification of an antiviral nucleoside agent (D,L-FMAU, 2 '-fluoro-5-methyl-beta,D,L-arabinofurano-syluracil) by mass spectrometry", J MED CHEM, 44(22), 2001, pp. 3541-3544

Abstract

A novel mass spectrometric method is applied to rapid, accurate (<1%) quantification of chiral Clevudine (L-FMAU, 2'-fluoro-5-methyl-beta ,L-arabinofuranosyluracil), a potent antiviral nucleoside agent against hepatitis B virus. Transition metal bound complex ions containing the chiral drug are generated by electrospray ionization mass spectrometry and subjected to collision-induced dissociation. The ratio of the two competitive dissociation rates is related to the enantiomeric composition of the drug mixture, allowingthe determination of enantiomerie contamination in the drug.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:54:10