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Titolo:
Sources of eicosanoid precursor fatty acid pools in tissues
Autore:
Zhou, L; Nilsson, A;
Indirizzi:
Univ Lund Hosp, Dept Med, Div Gastroenterol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 v Gastroenterol, S-22185 Lund, Sweden
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 10, volume: 42, anno: 2001,
pagine: 1521 - 1542
SICI:
0022-2275(200110)42:10<1521:SOEPFA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; DIETARY ARACHIDONIC-ACID; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; SCAVENGER RECEPTOR BI; ALPHA-LINOLENIC ACID; CHROMATOGRAPHY-MASS SPECTROMETRY; PHOSPHOLIPID TRANSFER PROTEIN; PROLIFERATOR-ACTIVATED RECEPTORS; OMEGA-3 EICOSAPENTAENOIC ACID; CHYLOMICRON REMNANT REMOVAL;
Keywords:
arachidonic acid; central nervous system; chylomicron; cholesteryl ester; CETP; dietary fatty acids; docosahexaenoic acid; eicosapentaenoic acid; free fatty acids; gastrointestinal tract; hepatic lipase; interconversion; LCAT; linoleic acid; lipoproteins; lipoprotein lipase; 2-acyl-lysophosphatidylcholine; phospholipids; platelets; SR-BI; triglycerides;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
319
Recensione:
Indirizzi per estratti:
Indirizzo: Nilsson, A Univ Lund Hosp, Dept Med, Div Gastroenterol, BMC B11,Tornavagen10, S-22185 Lund, Sweden Univ Lund Hosp BMC B11,Tornavagen 10 Lund SwedenS-22185 weden
Citazione:
L. Zhou e A. Nilsson, "Sources of eicosanoid precursor fatty acid pools in tissues", J LIPID RES, 42(10), 2001, pp. 1521-1542

Abstract

Tissue arachidonic acid (AA) pools originate from the diet, and from hepatic and extrahepatic desaturation-elongation of dietary linoleic acid (LA). This review summarizes the roles of absorption, transport, and formation ofAA in the buildup of tissue AA pools. In humans who ingest 0.2-0.3 g of AAand 10-20 g of LA per day on a Western diet, the formation of AA from LA exceeds the dietary supply of AA. A number of factors favor the partitioningof AA to tissue phospholipids rather than adipose tissue and plasma triglycerides. The characteristics of AA transport with lipoproteins are discussed with focus on the role of lipoprotein lipase, lecithin:cholesterol acyltransferase, hepatic lipase, and the scavenger receptor III and LDL receptorsin tissue uptake of AA. Liver-derived 2-acyl-lysophosphatidylcholine and plasma free AA are two important sources of AA for extrahepatic tissues which exhibit a low rate of uptake of lipoprotein AA. Desaturation-elongation of LA to produce AA occurs both in liver and in extrahepatic tissues, plasmafree LA being an important substrate particularly during fasting. The AA preference of the reacylation and transacylation reactions is crucial for the selective retention of AA in phospholipids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:29:21