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Titolo:
Role of ABCG1 and other ABCG family members in lipid metabolism
Autore:
Schmitz, G; Langmann, T; Heimerl, S;
Indirizzi:
Univ Regensburg, Inst Clin Chem & Lab Med, D-93042 Regensburg, Germany Univ Regensburg Regensburg Germany D-93042 , D-93042 Regensburg, Germany
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 10, volume: 42, anno: 2001,
pagine: 1513 - 1520
SICI:
0022-2275(200110)42:10<1513:ROAAOA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA WHITE GENE; CHROMOSOME 21Q22.3; HUMAN HOMOLOG; DIETARY-CHOLESTEROL; MOLECULAR-CLONING; HALF-TRANSPORTER; PROTEIN COMPLEX; PLASMA-MEMBRANE; SITOSTEROLEMIA; BINDING;
Keywords:
adaptor proteins; Drosophila ABC transporters; gene regulation; macrophage; beta-sitosterolemia; vesicular transport;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Schmitz, G Univ Regensburg, Inst Clin Chem & Lab Med, Franz Josef Strauss Allee 11, D-93042 Regensburg, Germany Univ Regensburg Franz Josef Strauss Allee 11 Regensburg Germany D-93042
Citazione:
G. Schmitz et al., "Role of ABCG1 and other ABCG family members in lipid metabolism", J LIPID RES, 42(10), 2001, pp. 1513-1520

Abstract

The molecular cloning and identification of mutations in ATP-binding cassette transporters in hereditary diseases have greatly expanded our knowledgeof the normal physiology of intracellular lipid transport processes. In addition to the well-known ATP-binding cassette transporter A1 (ABCA1) molecule, ABC transporters belonging to the ABCG (NVhite) subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be critically involved in the regulation oflipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1, the product of a sterol-induced gene, participates in cholesterol and phospholipid efflux. The ABCG5 and ABCG8 transporters, defective in beta -sitosterolemia, are also now considered interesting targets in the control and influence of total body sterol homeostasis. In this review, advances referring to the regulation and function of ABCG half-size transporters are summarized and discussed. In addition, new implications for the transcriptional control, as well as the intracellular routing and localization, of these proteins are presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:31:39