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Titolo:
Synthesis of [C-11]levofloxacin
Autore:
Berridge, MS; Burnazi, EM;
Indirizzi:
Case Western Reserve Univ, Sch Med, Dept Radiol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
fascicolo: 12, volume: 44, anno: 2001,
pagine: 859 - 864
SICI:
0362-4803(20011030)44:12<859:SO[>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; KINETICS; DEPOSITION; ZANAMIVIR; ACETONIDE;
Keywords:
levofloxacin; antibiotic; methyl iodide; regioselective; carbon-11;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Berridge, MS Case Western Reserve Univ, Sch Med, Dept Radiol, 11100 EuclidAve, Cleveland, OH 44106 USA Case Western Reserve Univ 11100 Euclid Ave Cleveland OH USA 44106
Citazione:
M.S. Berridge e E.M. Burnazi, "Synthesis of [C-11]levofloxacin", J LABEL C R, 44(12), 2001, pp. 859-864

Abstract

Levofloxacin, the pure S enantiomer of the fluoroquinolone antibiotic ofloxacin, was labeled via methylation of the corresponding, des-methyl, secondary amine with N.C.A. [C-11]methyl iodide. The methylation reaction was regioselective, giving predominantly the preferred methyl amine at high temperature in DMF, while otherwise giving predominantly the methyl ester of a free carboxylic acid also present in the molecule. Levofloxacin was obtained in 80% chemical yield after a 45 min synthesis. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 14:07:46