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Titolo:
Increased burst firing in substantia nigra pars reticulata neurons and enhanced response to selective D2 agonist in hemiparkinsonian rats after repeated administration of apomorphine
Autore:
Lee, JI; Shin, HJ; Nam, DH; Kim, JS; Hong, SC; Shin, HJ; Park, K; Eoh, W; Kim, JH; Lee, WY;
Indirizzi:
Sung Kyun Kwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol & Neurosurg, Seoul 135710, South Korea Sung Kyun Kwan Univ Seoul South Korea 135710 , Seoul 135710, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 5, volume: 16, anno: 2001,
pagine: 636 - 642
SICI:
1011-8934(200110)16:5<636:IBFISN>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTOR STIMULATION; GLOBUS-PALLIDUS NEURONS; PARKINSONS-DISEASE; SUBTHALAMIC NUCLEUS; 6-HYDROXYDOPAMINE-LESIONED RATS; NIGROSTRIATAL PATHWAY; LEVODOPA THERAPY; GENE-EXPRESSION; LESIONED RATS; BROMOCRIPTINE;
Keywords:
parkinsonian disorders; quinpirole; dyskinesias; substantia nigra;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, JI Sung Kyun Kwan Univ, Sch Med, Samsung Med Ctr, Dept Neurosurg,Kangnam Gu, 50 Ilwon Dong, Seoul 135710, South Korea Sung Kyun Kwan Univ 50 Ilwon Dong Seoul South Korea 135710 Korea
Citazione:
J.I. Lee et al., "Increased burst firing in substantia nigra pars reticulata neurons and enhanced response to selective D2 agonist in hemiparkinsonian rats after repeated administration of apomorphine", J KOR MED S, 16(5), 2001, pp. 636-642

Abstract

Intermittent administrations of dopaminergic agents in hemiparkinsonian rat enhances the behavioral response to subsequent administration of the drugs. This phenomenon is known as "priming" and thought as comparable to drug-induced dyskinesia in patients with Parkinson's disease. We investigated the behavioral and electrophysiological changes in 6-hydroxydopamine (6-OHDA)-lesioned hemiparkinsonian rats after repeated administrations of apomorphine. Administration of apomorphine (0.32 mg/kg, intraperitoneal, i.p.) twicedaily for 6 days enhanced the rotation induced by apomorphine from 341 turns/hour at the beginning to 755 turns/hr at the end. At the same time, the response to selective D2 agonist quinpirole (0.26 mg/kg, i.p.) was also enhanced from 203 to 555 turns/hr. Extracellular single unit recording revealed no significant difference in the basal firing rates of substantia nigra pars reticulata (SNr) neurons between the ipsilateral and contralateral sideof the 6-OHDA lesion regardless of the repeated administrations of apomorphine. In SNr of the lesion side, the units with burst firing pattern were found more frequently after repeated administrations of apomorphine and the suppressive effect of quinpirole on the firing rate was enhanced. These findings suggest that the increased percentage of the burst units is the important electrophysiological change in the development of enhanced response toselective D2 agonist.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 21:06:32