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Titolo:
Urinary N-acetyl-beta-D-glucosaminidase and malondialdehyde as a markers of renal damage in burned patients
Autore:
Kang, HK; Kim, DK; Lee, BH; Om, AS; Hong, JH; Koh, HC; Lee, CH; Shin, IC; Kang, JS;
Indirizzi:
Hanyang Univ, Coll Med, Dept Pharmacol, Sungdong Gu, Seoul 133791, South Korea Hanyang Univ Seoul South Korea 133791 dong Gu, Seoul 133791, South Korea Hallym Univ, Coll Med, Dept Surg, Pyungchon, South Korea Hallym Univ Pyungchon South Korea ed, Dept Surg, Pyungchon, South Korea Hanyang Univ, Coll Med, Inst Biomed Sci, Seoul 133791, South Korea HanyangUniv Seoul South Korea 133791 med Sci, Seoul 133791, South Korea Hanyang Univ, Coll Human Ecol, Dept Food & Nutr, Seoul, South Korea Hanyang Univ Seoul South Korea ol, Dept Food & Nutr, Seoul, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 5, volume: 16, anno: 2001,
pagine: 598 - 602
SICI:
1011-8934(200110)16:5<598:UNAMAA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERMAL-INJURY; TUBULAR MALFUNCTION; LIPID-PEROXIDATION; APOLIPOPROTEIN-H; EXCRETION; BETA-2-MICROGLOBULIN; DISEASE;
Keywords:
burns; wounds and injuries; kidney; blood urea nitrogen; ceatinine clearance; acetyl glucosaminidase; malondialdehyde;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kang, JS Hanyang Univ, Coll Med, Dept Pharmacol, Sungdong Gu, 17 HaengdangDong, Seoul 133791, South Korea Hanyang Univ 17 Haengdang Dong Seoul South Korea 133791 th Korea
Citazione:
H.K. Kang et al., "Urinary N-acetyl-beta-D-glucosaminidase and malondialdehyde as a markers of renal damage in burned patients", J KOR MED S, 16(5), 2001, pp. 598-602

Abstract

This study was aimed to evaluate renal dysfunction during three weeks after the burn injuries in 12 patients admitted to the Hallym University Hankang Medical Center with flame burn injuries (total body surface area, 20-40%). Parameters assessed included 24-hr urine volume, blood urea nitrogen, serum creatinine, creatinine clearance, total urinary protein, urinary microalbumin, 24-hr urinary N-acetyl-beta -D-glucosaminidase (NAG) activity, and urinary malondialdehyde (MDA). Statistical analysis was performed using repeated measures ANOVA test. The 24-hr urine volume, creatinine clearance, andurinary protein significantly increased on day 3 post-burn and fell thereafter. The urine microalbumin excretion showed two peak levels on day 0 post-burn and day 3. The 24-hr urinary NAG activity significantly increased to its maximal level on day 7 post-burn and gradually fell thereafter. The urinary MDA progressively increased during 3 weeks after the burn injury. Despite recovery of general renal function through an intensive care of burn injury, renal tubular damage and lipid peroxidation of the renal tissue suggested to persist during three weeks after the burn. Therefore, a close monitoring and intensive management of renal dysfunction is necessary to preventburn-induced acute renal failure as well as to lower mortality in patientswith major burns.

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Documento generato il 19/09/20 alle ore 18:14:26