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Titolo:
The relationship of histologic activity to serum ALT, HCV genotype and HCVRNA titers in chronic hepatitis C
Autore:
Lee, YS; Yoon, SK; Chung, ES; Bae, SH; Choi, JY; Han, JY; Chung, KW; Sun, HS; Kim, BS; Kim, BK;
Indirizzi:
Catholic Univ, Dept Internal Med, Coll Med, Seoul, South Korea Catholic Univ Seoul South Korea ernal Med, Coll Med, Seoul, South Korea Catholic Univ, Dept Pathol, Coll Med, Seoul, South Korea Catholic Univ Seoul South Korea pt Pathol, Coll Med, Seoul, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 5, volume: 16, anno: 2001,
pagine: 585 - 591
SICI:
1011-8934(200110)16:5<585:TROHAT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; CHRONIC LIVER-DISEASE; VIRUS-RNA; POSITIVE SUBJECTS; INTERFERON-ALPHA; ANTI-HCV; INFECTION; VIREMIA; CARRIERS; FEATURES;
Keywords:
hepatitis C, chronic; histology; reverse transcriptiase-polymerase chain reaction; genotype; alanine transaminase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Yoon, SK Catholic Univ, Dept Internal Med, Kangnam St Marys Hosp, Seocho Ku, 505 Banpo Dong, Seoul 137701, South Korea Catholic Univ 505 Banpo Dong Seoul South Korea 137701 outh Korea
Citazione:
Y.S. Lee et al., "The relationship of histologic activity to serum ALT, HCV genotype and HCVRNA titers in chronic hepatitis C", J KOR MED S, 16(5), 2001, pp. 585-591

Abstract

It is unclear whether serum ALT levels or virological characteristics of hepatitis C virus(HCV) including HCV genotypes and HCV RNA titers, can reflect the degree of histological injury in chronic hepatitis C. The aim of this study was to investigate the relationships between the levels of histological damage and serum ALT levels, HCV genotypes or circulating HCV RNA titers in chronic hepatitis C. A total of 56 patients underwent liver biopsy and the histological activity index (HAI) was evaluated by Knodell's scoring system. HCV genotype by RT-nested PCR and HCV RNA quantitation by competitive RT-PCR were performed. Thirty-four patients were infected with HCV genotype 1b, 20 patients with genotype 2a, and 2 patients with undetermined type. Serum ALT levels were not positively correlated with total HAI score or HCV RNA titers, but showed a linear correlation with scores of piecemeal necrosis (r=0.32, p <0.05) and portal inflammation (r=0.27, p <0.05). HCV genotype had no significant correlation with RNA titers, HAI score or with serum ALT levels. Also, no statistical relationship was seen between HCV RNA titer and HAI score. These results suggest that liver histology is essential to evaluate the severity of chronic hepatitis C precisely.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:00:40