Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Genotyping CagA, VacA subtype, IceA1, and BabA of Helicobacter pylori isolates from Korean patients, and their association with gastroduodenal diseases
Autore:
Kim, SY; Woo, CW; Lee, YM; Son, BR; Kim, JW; Chae, HB; Youn, SJ; Park, SM;
Indirizzi:
Chungbuk Natl Univ, Coll Med, Dept Internal Med, Hungduk Ku, Cheongju 361763, South Korea Chungbuk Natl Univ Cheongju South Korea 361763 ongju 361763, South Korea Chungbuk Natl Univ, Coll Med, Dept Microbiol, Cheongju 361763, South KoreaChungbuk Natl Univ Cheongju South Korea 361763 ongju 361763, South Korea Chungbuk Natl Univ, Coll Med, Dept Clin Pathol, Cheongju 361763, South Korea Chungbuk Natl Univ Cheongju South Korea 361763 ongju 361763, South Korea Med Res Inst, Cheongju, South Korea Med Res Inst Cheongju South KoreaMed Res Inst, Cheongju, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 5, volume: 16, anno: 2001,
pagine: 579 - 584
SICI:
1011-8934(200110)16:5<579:GCVSIA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC EPITHELIAL-CELLS; VACUOLATING CYTOTOXIN; VIRULENCE FACTORS; CLINICAL RELEVANCE; STRAINS; GENE; EXPRESSION; INFECTION; JAPAN; ANTIGENS;
Keywords:
Helicobacter pylori; CagA; VacA; IceA1; BabA; peptic ulcer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Park, SM Chungbuk Natl Univ, Coll Med, Dept Internal Med, Hungduk Ku, San 48,Gaeshin Dong, Cheongju 361763, South Korea Chungbuk Natl Univ San 48,Gaeshin Dong Cheongju South Korea 361763
Citazione:
S.Y. Kim et al., "Genotyping CagA, VacA subtype, IceA1, and BabA of Helicobacter pylori isolates from Korean patients, and their association with gastroduodenal diseases", J KOR MED S, 16(5), 2001, pp. 579-584

Abstract

The genetic status of cagA, vacA subtype, iceA1, and babA, and the relationship to gastroduodenal diseases were assessed in Helicobacter pylori isolates in Korea. Seventy-six strains of H. pylori were isolated from the antrum and the corpus of 41 adult patients (22 with peptic ulcer and 19 with gastritis). The cagA, iceA1, and babA genes were assessed by polymerase chain reaction and the vacA subtypes were determined by reverse hybridization-line probe assay. The positive rates of 349-bp cagA, 208-bp cagA, iceA1, and babA genes were 97.4%,96.1%,84,2%, and 36.1%, respectively. The vacA s1a, s1b, s1c, and s2 variants were detected in 11.8%, 3.9%, 80.4%, and 1.3%, respectively. ml (78.9%) is more prevalent than m2 (5.3%). The most common vacAgenotype was s1c/m1 (61.9%), and 14 isolates (18.4%) contained mixed vacA genotypes from a single biopsy specimen. Twenty-one (60%) of 35 patients were infected with more than two strains of different cagA, iceA1, babA, and vacA genotypes. None of cagA, iceA1, babA, and vacA s1/m1 were associated with peptic ulcer. In conclusion, most H. pylori isolates in Korea carry cagA, iceA1, and vacA s1c/m1 genes, and reside with multiple strains. These genes do not correlate with the peptic ulcer in the Korean patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:00:34