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Titolo:
Different distribution patterns of the two mannose 6-phosphate receptors in rat liver
Autore:
Waguri, S; Kohmura, M; Kanamori, S; Watanabe, T; Ohsawa, Y; Koike, M; Tomiyama, Y; Wakasugi, M; Kominami, E; Uchiyama, Y;
Indirizzi:
Osaka Univ, Dept Cell Biol & Neurosci A1, Grad Sch Med, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Sch Med, Suita, Osaka 5650871, Japan Juntendo Univ, Sch Med, Dept Biochem, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 v, Sch Med, Dept Biochem, Tokyo 113, Japan
Titolo Testata:
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
fascicolo: 11, volume: 49, anno: 2001,
pagine: 1397 - 1405
SICI:
0022-1554(200111)49:11<1397:DDPOTT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-II; CATHEPSIN-B; LYSOSOMAL-ENZYMES; CYSTEINE PROTEINASES; IMMUNOCYTOCHEMICAL LOCALIZATION; INTRACELLULAR TRAFFICKING; DEFICIENT FIBROBLASTS; LIGAND INTERACTIONS; CYTOPLASMIC TAIL; DENDRITIC CELLS;
Keywords:
mannose 6-phosphate receptors; immunofluorescence; hepatocytes; Kupffer cells; antigen-presenting cells; rat; liver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Waguri, S Osaka Univ, Dept Cell Biol & Neurosci A1, Grad Sch Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 650871, Japan
Citazione:
S. Waguri et al., "Different distribution patterns of the two mannose 6-phosphate receptors in rat liver", J HIST CYTO, 49(11), 2001, pp. 1397-1405

Abstract

Two mannose 6-phosphate receptors, cation-dependent and -independent receptors (CDMPR and CIMPR), play an important role in the intracellular transport of lysosomal enzymes. To investigate functional differences between the two in vivo, their distribution was examined in the rat liver using immunohistochemical techniques. Positive Signals corresponding to CIMPR were detected intensely in hepatocytes and weakly in sinusoidal Kupffer cells and interstitial cells in Glisson's capsule. In the liver acinus, hepatocytes in the perivenous region showed a more intense immunoreactivity than those in the periportal region. On the other hand, positive staining of CDMPR was detected at a high level in Kupffer cells, epithelial cells of interlobular bile ducts, and fibroblast-like cells, but the corresponding signal was rather weak in hepatocytes. In situ hybridization analysis also revealed a high level of expression of CIMPR mRNAs in hepatocytes and of CDMPR mRNA in Kupffer cells. By double immunostaining, OX6-positive antigen-presenting cells in Glisson's capsule were co-labeled with the CDMPR signal but were only faintly stained with anti-CIMPR. These different distribution patterns of thetwo MPRs suggest distinct functional properties of each receptor in liver tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 19:16:58