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Titolo:
Phenotypic characterization of Lith genes that determine susceptibility tocholesterol cholelithiasis in inbred mice: soluble pronucleating proteins in gallbladder and hepatic biles
Autore:
van Erpecum, KJ; Wang, DQH; Lammert, F; Paigen, B; Groen, AK; Carey, MC;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Gastroenterol, NL-3508 GA Utrecht, NetherlandsUniv Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Harvard Univ, Sch Med, Dept Med, Boston, MA USA Harvard Univ Boston MA USA rvard Univ, Sch Med, Dept Med, Boston, MA USA Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 roenterol, Boston, MA 02115 USA Harvard Digest Dis Ctr, Boston, MA USA Harvard Digest Dis Ctr Boston MA USA vard Digest Dis Ctr, Boston, MA USA Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Jackson Lab, Bar Harbor, ME 04609 USA Jackson Lab Bar Harbor ME USA 04609Jackson Lab, Bar Harbor, ME 04609 USA
Titolo Testata:
JOURNAL OF HEPATOLOGY
fascicolo: 4, volume: 35, anno: 2001,
pagine: 444 - 451
SICI:
0168-8278(200110)35:4<444:PCOLGT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILIARY ALPHA(1)-ACID GLYCOPROTEIN; GALLSTONE FORMATION; AMINOPEPTIDASE-N; LIPID-CONCENTRATION; CRYSTAL NUCLEATION; BINDING-PROTEIN; MODEL BILE; CRYSTALLIZATION; IMMUNOGLOBULINS; SECRETION;
Keywords:
bile; bile salts; gallbladder; gallstone; hepatic; mouse; protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: van Erpecum, KJ Univ Utrecht, Med Ctr, Dept Gastroenterol, POB 85500, NL-3508 GA Utrecht, Netherlands Univ Utrecht POB 85500 Utrecht Netherlands NL-3508 GA nds
Citazione:
K.J. van Erpecum et al., "Phenotypic characterization of Lith genes that determine susceptibility tocholesterol cholelithiasis in inbred mice: soluble pronucleating proteins in gallbladder and hepatic biles", J HEPATOL, 35(4), 2001, pp. 444-451

Abstract

Background/Aims: Gallstone susceptibility is high in C57L inbred mice (males > females) and low in AKR mice, related to variant lithogenic (Lith) genes. We examined the relationship between biliary crystallization-promoting proteins and gallstone susceptibility. Methods: Biliary protein and lipid concentrations were determined at 0, 7,14, 21, 28 and 56 days on a lithogenic diet. Results: Protein and soluble mucin concentrations in gallbladder biles increased markedly in males, but remained low in females of both strains and correlated with the cholesterol saturation index (CST). In all groups, IgA and IgM concentrations decreased initially, but increased at later stages. There were no consistent changes in IgG concentrations, but aminopeptidase-Nlevels were higher in AKR than in C57L. During the lithogenic diet period,the CST was greater than or equal to 2 in C57L males, approximate to 1.5 in AKR males, and approximate to I in females of both strains. Taurodeoxycholate and taurochenodeoxycholate rose sharply in C57L, but remained low in AKR. Conclusions: Hydrophobic bile salts, cholesterol supersaturation, and possibly, high mucin concentrations are associated with gallstone formation. Invitro crystallization-promoting immunoglobulins and aminopeptidase-N do not appear to be major factors in murine gallstone pathogenesis, in line withthe observation that genes encoding these proteins do not co-localize withany known Lith locus (C) 2001 European Association for the Study of the Liver. Published by Elsevier Science BN. All rights reserved.

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Documento generato il 28/09/20 alle ore 15:42:08