Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Instability of chromosome 17 and the p53 locus in non-familial colorectal cancer with multiple primary malignancies
Autore:
Sawai, T; Nanashima, A; Tsuji, T; Yamaguchi, H; Yasutake, T; Nakagoe, T; Ayabe, H; Tagawa, Y;
Indirizzi:
Nagasaki Univ, Sch Med, Dept Surg 1, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 ept Surg 1, Nagasaki 8528501, Japan
Titolo Testata:
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
fascicolo: 3, volume: 20, anno: 2001,
pagine: 401 - 405
SICI:
0392-9078(200109)20:3<401:IOC1AT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; NUMERICAL ABERRATIONS; CARCINOMAS; GENE; ADENOCARCINOMAS;
Keywords:
multiple primary cancer; colorectal cancer; chromosomal instability; chromosome 17; p53; fluorescence in situ hybridization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Sawai, T Nagasaki Univ, Sch Med, Dept Surg 1, 7-1 Sakamoto, Nagasaki 8528501, Japan Nagasaki Univ 7-1 Sakamoto Nagasaki Japan 8528501 8528501, Japan
Citazione:
T. Sawai et al., "Instability of chromosome 17 and the p53 locus in non-familial colorectal cancer with multiple primary malignancies", J EXP CL C, 20(3), 2001, pp. 401-405

Abstract

Recently, two different mechanisms of genetic instability have been demonstrated in the carcinogenesis of colorectal cancer. Microsatellite instability is an important genetic event for carcinogenesis in hereditary non-polyposis colorectal cancer, proximal colon cancer, and multiple colorectal. carcinoma. To examine the association among chromosomal instability and multiple primary malignancies (MPM) in colorectal cancer, fluorescence in situ hybridization using a chromosome 17-specific probe, p53 cosmid probe, and/or an alpha satellite DNA probe was performed in 184 patients with colorectal.cancer. The proportion of aneusomy 17 in MPM was significantly higher thanthat of single cancers (SC) (46.1+/-8.0% and 39.0+/-10.3%, respectively; p<0.01). Multiple numerical aberrations of chromosome 17 in MPM occurred more often than those of SC (64.3% and 22.9%, respectively; p<0.01). The mean frequency of p53 deletion was also higher in MPM (70.4+/-16.7%) compared with SC (53.4+/-18.1%, p<0.05). The frequency of chromosome 17 translocation was significantly greater in tumors with MPM (4/6; 67%) than in SC (3/23; 13%, p<0.05). The frequency of p53 locus translocation was also significantly greater in tumors with MPM (4/6; 67%) than in SC (0/23; 0%, p<0.01). These results suggested that numerical and structural aberrations of chromosome17 and the p53 locus are important genetic events associated with carcinogenesis in non-familial colorectal cancer with MPM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 06:22:07