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Titolo:
Hereditary dilated cardiomyopathy in Holstein-Friesian cattle in Japan: Association with hereditary myopathy of the diaphragmatic muscles
Autore:
Furuoka, H; Yagi, S; Murakami, A; Honma, A; Kobayashi, Y; Matsui, T; Miyahara, K; Taniyama, H;
Indirizzi:
Obihiro Univ Agr & Vet Med, Dept Vet Pathol, Obihiro, Hokkaido 0808555, Japan Obihiro Univ Agr & Vet Med Obihiro Hokkaido Japan 0808555 0808555, Japan Obihiro Univ Agr & Vet Med, Dept Vet Clin Radiol, Obihiro, Hokkaido 0808555, Japan Obihiro Univ Agr & Vet Med Obihiro Hokkaido Japan 0808555 0808555, Japan Kushiro Agr Mutual Aid Assoc, Shibecha Chou 0882338, Japan Kushiro Agr Mutual Aid Assoc Shibecha Chou Japan 0882338 0882338, Japan Rakuno Gakuen Univ, Sch Vet Med, Dept Vet Pathol, Ebetsu, Hokkaido 0698501, Japan Rakuno Gakuen Univ Ebetsu Hokkaido Japan 0698501 Hokkaido 0698501, Japan
Titolo Testata:
JOURNAL OF COMPARATIVE PATHOLOGY
fascicolo: 2-3, volume: 125, anno: 2001,
pagine: 159 - 165
SICI:
0021-9975(200108/10)125:2-3<159:HDCIHC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANIMAL-MODEL; MUTATIONS; DYSTROPHY; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Furuoka, H Obihiro Univ Agr & Vet Med, Dept Vet Pathol, Obihiro, Hokkaido 0808555, Japan Obihiro Univ Agr & Vet Med Obihiro Hokkaido Japan 0808555 apan
Citazione:
H. Furuoka et al., "Hereditary dilated cardiomyopathy in Holstein-Friesian cattle in Japan: Association with hereditary myopathy of the diaphragmatic muscles", J COMP PATH, 125(2-3), 2001, pp. 159-165

Abstract

This report deals with the pathology and genetic basis of dilated cardiomyopathy in 10 Holstein-Friesian cows aged 3-6 years, a disease similar to that reported in Simmental-Red Holstein and Holstein-Friesian cattle in several other countries. The main clinical signs were associated with systemic circulatory failure, and at necropsy the animals showed cardiomegaly, severecongestion and fibrosis of the liver, and systemic cardiac oedema. Histologically, hypertrophy and vacuolation of the cardiac muscle fibres and severe fibrosis were noted. Electron microscopically, the sarcoplasm of the hypertrophic fibres was seen to be filled with fine structures of low electron-density, together with thin filamentous material, suggesting myofibrillar lysis, The mitochondria, showed increased size, an abnormal cristae pattern and vacuolation due to partial loss of cristae. Pedigree analysis of the affected cattle indicated an autosomal recessive mode of inheritance, The family line of this cardiomyopathy overlapped with that of hereditary myopathyof the diaphragmatic muscles in Holstein-Friesian cattle, the pathologicalaspects and inheritance mode of which were reported previously. The available evidence suggested a genetic association between these two pathologically distinct diseases. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:02:21