Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Sertaconazole: In-vitro antifungal activity against vaginal and other superficial yeast isolates
Autore:
Carrillo-Munoz, AJ; Brio, S; Quindos, G; Palacin, C; Guglietta, A; Espinel-Ingroff, A;
Indirizzi:
ACIA, Dept Microbiol, E-08080 Barcelona, Spain ACIA Barcelona Spain E-08080 A, Dept Microbiol, E-08080 Barcelona, Spain
Titolo Testata:
JOURNAL OF CHEMOTHERAPY
fascicolo: 5, volume: 13, anno: 2001,
pagine: 555 - 562
SICI:
1120-009X(200110)13:5<555:SIAAAV>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNGAL-INFECTIONS; CANDIDA-ALBICANS; EPIDEMIOLOGY; DNA; BIFONAZOLE;
Keywords:
NeoSensitabs; Candida; sertaconazole; fluconazole; itraconazole; clotrimazole; tioconazole; miconazole; econazole; ketoconazole; amphotericin B; flucytosine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Carrillo-Munoz, AJ ACIA, Dept Microbiol, POB 10178, E-08080 Barcelona, Spain ACIA POB 10178 Barcelona Spain E-08080 arcelona, Spain
Citazione:
A.J. Carrillo-Munoz et al., "Sertaconazole: In-vitro antifungal activity against vaginal and other superficial yeast isolates", J CHEMOTHER, 13(5), 2001, pp. 555-562

Abstract

The in vitro susceptibilities of 183 clinical yeast isolates to sertaconazole (STZ) were compared to their susceptibilities to clotrimazole (CTZ), econazole (ECZ), ketoconazole (KTZ), miconazole (MNZ), fluconazole (FLZ), itraconazole (ITZ), tioconazole (TCZ), amphotericin B (AMB) and flucytosine (5FC) by using a commercial agar diffusion method. Strains were isolated fromvaginal and other superficial clinical samples (18 species of Candida and five strains belonging to other yeast genera). Only one strain (0.5%) was resistant to STZ out of 87.4% of susceptible strains (n=160). The percentageof susceptible strains was higher than those obtained with the other agents evaluated and the percentage of resistant strains was lower than for mostof the other antifungals. The pattern of susceptibility of C. albicans to STZ, TCZ, ITZ and CLZ was similar and superior to the pattern of susceptibility of this species to MNZ, ECZ, FLZ, 5FC and KTZ. C. dubliniensis was more susceptible to STZ, MNZ, MNZ, FLZ, ITZ, CLZ than to TCZ, ECZ, 5FC, AMB orKTZ. Ten susceptible strains to STZ were resistant to FLZ and one strain was resistant to ITZ. The overall antifungal activity of STZ in vitro against a wide range of clinically important yeasts from vaginal and cutaneous samples indicates the therapeutic potential of this agent for the treatment of infections caused by these fungi. However, the activity of STZ and the clinical value of in vitro data need to be verified in human clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:18:58