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Titolo:
pH paradox and neonatal heart
Autore:
Baron, O; Saiki, Y; Rebeyka, IM;
Indirizzi:
C Heritage Med Res Ctr 261, Cardiovasc Res Grp, Edmonton, AB, Canada C Heritage Med Res Ctr 261 Edmonton AB Canada Grp, Edmonton, AB, Canada
Titolo Testata:
JOURNAL OF CARDIOVASCULAR SURGERY
fascicolo: 4, volume: 42, anno: 2001,
pagine: 475 - 480
SICI:
0021-9509(200108)42:4<475:PPANH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA+-H+ EXCHANGE; REPERFUSION INJURY; RABBIT HEART; SARCOPLASMIC-RETICULUM; DEVELOPMENTAL-CHANGES; MYOCARDIAL ISCHEMIA; CARDIAC PHYSIOLOGY; INTRACELLULAR PH; GLOBAL-ISCHEMIA; PROTECTION;
Keywords:
sodium-calcium exchanger; myocardial ischemia; myocardial reperfusion injury; rabbits;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Baron, O Hop G&R Laennec, Dept Cardiothorac Surg, Bd J Monod, F-44093 Nantes, France Hop G&R Laennec Bd J Monod Nantes France F-44093 Nantes, France
Citazione:
O. Baron et al., "pH paradox and neonatal heart", J CARD SURG, 42(4), 2001, pp. 475-480

Abstract

To evaluate the functional status of the Na+/H+ exchanger in the neonatal heart. Methods. On the Langendorff system, isolated neonatal rabbit hearts were arrested by using cardioplegia with or without a specific Na+/H+ exchanger blocker, 5-(N,N dimethyl) amiloride (DMA) (20 muM). Ischemic period was 40 minutes at 37 degreesC or 120 minutes at 20 degreesC before 30 minutesof reperfusion at 37 degreesC. When DMA was added to the cardioplegia solution, it was also added to the reperfusate for the first 5 minutes of reperfusion (20 muM). Results. Postischemic developed pressure was 50.3 +/-7.1 mmHg in the DMA group versus 25.9 +/-6 min g in the control group (P <0.05) at 37 degreesC and 74.8 +/- 14.6 mmHg in the DMA group versus 60.6 +/- 11.5mmHg in the control group (p <0.05) at 20 degreesC. Postischeimic diastolic pressure was 40.4 +/-3.3 mmHg in the DMA group versus 28.4 +/-7 mmHg in the control group (p <0.05) at 37 degreesC and 9.6 +/-3.1 mmHg in the DMA group versus 15 +/-3.7 in the control group (P <0.05) at 20 degreesC. Creatine kinase washout was 296 +/- 97 IU/L in the DMA group versus 1253 +/- 537 IU/L in the control group (p <0.05) at 37 degreesC and 370 +/- 156 IU/L in the DMA group versus 524 +/- 104 IU/L in the control group (P <0.05) at 20 degreesC. Conclusions. 1) The Na+/H+ exchanger is active in the neonatal heart. 2) The Na+/H+ exchanger plays a key-role in the pathogenesis of reperfusion injury of the neonatal myocardium. 3) This exchanger is sensitive evenfor low H+ transmembrane gradients and even under hypothermic conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:00:13