Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Immunohistochemical study on VEGF expression in endometrial carcinoma - comparison with p53 expression, angiogenesis, and tumor histologic grade
Autore:
Fujisawa, T; Watanabe, J; Akaboshi, M; Ohno, E; Kuramoto, H;
Indirizzi:
Kitasato Univ, Grad Sch Med Sci, Dept Clin Cytol, Sagamihara, Kanagawa 2288555, Japan Kitasato Univ Sagamihara Kanagawa Japan 2288555 , Kanagawa 2288555, Japan Kitasato Univ, Sch Med, Dept Pathol, Kanagawa, Japan Kitasato Univ Kanagawa Japan niv, Sch Med, Dept Pathol, Kanagawa, Japan Kitasato Univ, Sch Allied Hlth Sci, Dept Clin Cytol, Kanagawa, Japan Kitasato Univ Kanagawa Japan Hlth Sci, Dept Clin Cytol, Kanagawa, Japan
Titolo Testata:
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
fascicolo: 11, volume: 127, anno: 2001,
pagine: 668 - 674
SICI:
0171-5216(200111)127:11<668:ISOVEI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; VASCULAR-PERMEABILITY FACTOR; HUMAN COLON-CANCER; WILD-TYPE P53; PROGNOSTIC-SIGNIFICANCE; THYMIDINE PHOSPHORYLASE; MICROVESSEL DENSITY; GASTRIC-CARCINOMA; LUNG-CARCINOMA; MESSENGER-RNA;
Keywords:
VEGF; angiogenesis; MVC; p53; endometrial carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Fujisawa, T Kitasato Univ, Grad Sch Med Sci, Dept Clin Cytol, 15-1,1 Chome, Sagamihara, Kanagawa 2288555, Japan Kitasato Univ 15-1,1 Chome SagamiharaKanagawa Japan 2288555 n
Citazione:
T. Fujisawa et al., "Immunohistochemical study on VEGF expression in endometrial carcinoma - comparison with p53 expression, angiogenesis, and tumor histologic grade", J CANC RES, 127(11), 2001, pp. 668-674

Abstract

Objective: Vascular endothelial growth factor (VEGF) - that activates endothelial cell growth - has been considered to induce angiogenesis, which is indispensable to tumor-genesis and progression. In this study, an immunohistochemical analysis was carried out to clarify the correlation of VEGF expression with angiogenesis, p53 expression - of which the wild-type is considered to suppress VEGF expression - and histologic grade in endometrial carcinoma. Study design: Immunohistochemical staining for detecting VEGF protein, factor VIII-related antigen of endothelial cells, and p53 protein was performed by the labeled streptavidin-biotin method on the formalin-fixed andparaffin-embedded tumor tissue of 104 patients with endometrial (endometrioid) carcinoma, including 69 with well-differentiated, 25 with moderately differentiated, and ten with poorly differentiated adenocarcinoma. Results: The labeling index of p53 expression was 19.9 +/- 28.8% in the high VEGF group, whereas in the low VEGF group it was 12.2 +/- 17.0%, showing that VEGFexpression was significantly correlated with p53 expression (P < 0.05). VEGF expression, however, was not correlated with either the number of microvessels in the tumor area or tumor histologic grade. Conclusion: VEGF expression was not a single specific indicator of angiogenesis in endometrial carcinoma, whereas it was significantly correlated with p53 expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:12:02