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Titolo:
Genome and Hormones: Gender differences in physiology - Selected contribution: Gender differences in the endothelin-B receptor contribution to basal cutaneous vascular tone in humans
Autore:
Kellogg, DL; Liu, Y; Pergola, PE;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Med, Div Geriatr & Gerontol, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 & Gerontol, San Antonio, TX 78229 USA Univ Texas, Hlth Sci Ctr, Dept Med, Div Nephrol, San Antonio, TX 78229 USAUniv Texas San Antonio TX USA 78229 iv Nephrol, San Antonio, TX 78229 USA Dept Vet Affairs, Audie L Murphy Mem Vet Hosp Div, S Texas Vet Hlth Care Syst, Ctr Geriatr Res Educ & Clin, San Antonio, TX 78229 USA Dept Vet Affairs San Antonio TX USA 78229 Clin, San Antonio, TX 78229 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 91, anno: 2001,
pagine: 2407 - 2411
SICI:
8750-7587(2001)91:5<2407:GAHGDI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; HUMAN SKIN; ACTIVE VASODILATION; NITRIC-OXIDE; TAIL ARTERY; HEAT-STRESS; NEUROTRANSMISSION; COTRANSMISSION; ANTAGONIST; POTENT;
Keywords:
skin blood flow; laser-Doppler flowmetry; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kellogg, DL Univ Texas, Hlth Sci Ctr, Dept Med, Div Geriatr & Gerontol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA 78229 229 USA
Citazione:
D.L. Kellogg et al., "Genome and Hormones: Gender differences in physiology - Selected contribution: Gender differences in the endothelin-B receptor contribution to basal cutaneous vascular tone in humans", J APP PHYSL, 91(5), 2001, pp. 2407-2411

Abstract

To test whether the contribution of endothelin-B (ET-B) receptors to resting vascular tone differs between genders, we administered the ET-B receptorantagonist BQ-788 into the forearm skin of 11 male and 11 female subjects by intradermal microdialysis. Skin blood flow was measured using laser-Doppler flowmetry at the microdialysis site. The probe was perfused with Ringersolution alone, followed by BQ-788 (150 nM) and finally sodium nitroprusside (28 mM) to effect maximal cutaneous vasodilation. Cutaneous vascular conductance (CVC) was calculated (laser-Doppler flowmetry/mean arterial pressure) and normalized to maximal levels (% max). In male subjects, baseline CVC was (mean +/- SE) 19 +/- 3% max and increased to 26 +/- 5% max with BQ-788 (P< 0.05 vs. baseline). In female subjects, baseline CVC was 13 +/- 1% max and decreased to 10 +/- 1% max in response to BQ-788. CVC responses to BQ-788 differed with gender (P< 0.05); thus the contribution of ET-B receptors to resting cutaneous vascular tone differs between men and women. In men,ET-B receptors mediate tonic vasoconstriction, whereas, in women, ET-B receptors mediate tonic vasodilation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:49:17