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Titolo:
Genome and hormones: Gender differences in physiology - Selected contribution: Cerebrovascular NOS and cyclooxygenase are unaffected by estrogen in mice lacking estrogen receptor-alpha
Autore:
Geary, GG; McNeill, AM; Ospina, JA; Krause, DN; Korach, KS; Duckles, SP;
Indirizzi:
Univ Calif Irvine, Coll Med, Dept Pharmacol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 ept Pharmacol, Irvine, CA 92697 USA NIEHS, Res Triangle Pk, NC 27709 USA NIEHS Res Triangle Pk NC USA 27709NIEHS, Res Triangle Pk, NC 27709 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 91, anno: 2001,
pagine: 2391 - 2399
SICI:
8750-7587(2001)91:5<2391:GAHGDI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL NITRIC-OXIDE; VASCULAR INJURY RESPONSE; DEFICIENT MICE; GENE DISRUPTION; MECHANISMS; EXPRESSION; CELLS; BETA;
Keywords:
cerebral circulation; estrogen receptor-alpha knockout mice; nitric oxide synthase; gonadal steroids; ovariectomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Duckles, SP Univ Calif Irvine, Coll Med, Dept Pharmacol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 l, Irvine, CA 92697 USA
Citazione:
G.G. Geary et al., "Genome and hormones: Gender differences in physiology - Selected contribution: Cerebrovascular NOS and cyclooxygenase are unaffected by estrogen in mice lacking estrogen receptor-alpha", J APP PHYSL, 91(5), 2001, pp. 2391-2399

Abstract

Estrogen alters reactivity of cerebral arteries by modifying production ofendothelium-dependent vasodilators. Estrogen receptors (ER) are thought tobe involved, but the responsible ER subtype is unknown. ER-alpha knockout (alpha ERKO) mice were used to test whether estrogen acts via ER-alpha. Mice were ovariectomized, with or without estrogen replacement, and cerebral blood vessels were isolated 1 mo later. Estrogen increased levels of endothelial nitric oxide synthase and cyclooxygenase-1 in vessels from wild-type mice but was ineffective in alpha ERKO mice. Endothelium-denuded middle cerebral artery segments from all animals constricted when pressurized. In denuded arteries from alpha ERKO but not wild-type mice, estrogen treatment enhanced constriction. In endothelium-intact, pressurized arteries from wild-type estrogen-treated mice, diameters were larger compared with arteries from untreated wild-type mice. In addition, contractile responses to indomethacin were greater in arteries from wild-type estrogen-treated mice compared with arteries from untreated wild-type mice. In contrast, estrogen treatment of alpha ERKO mice had no effect on diameter or indomethacin responses ofendothelium-intact arteries. Thus ER-alpha regulation of endothelial nitric oxide synthase and cyclooxygenase-1 pathways appears to contribute to effects of estrogen on cerebral artery reactivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:40:15