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Titolo:
Bcl-2 mediates sex-specific differences in recovery of mice from LPS-induced signs of sickness independent of IL-6
Autore:
Tesfaigzi, Y; Rudolph, K; Fischer, MJ; Conn, CA;
Indirizzi:
Lovelace Resp Res Inst, Albuquerque, NM 87108 USA Lovelace Resp Res Inst Albuquerque NM USA 87108 Albuquerque, NM 87108 USA Univ New Mexico, Dept Nutr, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 Nutr, Albuquerque, NM 87131 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 91, anno: 2001,
pagine: 2182 - 2189
SICI:
8750-7587(2001)91:5<2182:BMSDIR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; TUMOR-NECROSIS-FACTOR; BCL-2-DEFICIENT MICE; PULMONARY-FUNCTION; GENE-EXPRESSION; IN-VIVO; ENDOTOXIN; APOPTOSIS; CYTOKINE; LUNG;
Keywords:
apoptosis; hypothermia; cytokines; inflammation; mucus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Tesfaigzi, Y Lovelace Resp Res Inst, 2425 Ridgecrest Dr, Albuquerque, NM 87108 USA Lovelace Resp Res Inst 2425 Ridgecrest Dr Albuquerque NM USA 87108
Citazione:
Y. Tesfaigzi et al., "Bcl-2 mediates sex-specific differences in recovery of mice from LPS-induced signs of sickness independent of IL-6", J APP PHYSL, 91(5), 2001, pp. 2182-2189

Abstract

Chronic pulmonary diseases are more common in boys than in girls. Therefore, we investigated the differences in signs of sickness in male and female mice that were exposed to lipopolysaccharide (LPS) by intranasal instillation. Because apoptosis is important in the resolution of inflammation, we tested the hypothesis that reduced levels of Bcl-2, a regulator of apoptosis,may play a role in gender-specific differences in response to inflammation. Bcl-2 wild-type (+/+) female mice recovered from an LPS-induced drop in body temperature and loss in body weight significantly faster than male (+/+) mice. Female heterozygous (+/-) mice showed reduced Bcl-2 levels and exhibited a slower recovery than female (+/+) mice that was similar to the recovery pattern in male (+/+) and (+/-) mice. Interleukin-6 (IL-6) activity levels in the bronchoalveolar lavage fluid were higher in male than in femalemice but were not different between (+/+) and (+/-) mice. We conclude thatBcl-2 plays a role in mediating the faster recovery of female (+/+) mice from LPS-induced signs of sickness independent of IL-6. These studies indicate that apoptotic mechanisms may be involved in gender-specific differencesin chronic pulmonary diseases.

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Documento generato il 01/12/20 alle ore 22:49:58