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Titolo:
Flow-independent nitric oxide exchange parameters in healthy adults
Autore:
Shin, HW; Rose-Gottron, CM; Perez, F; Cooper, DM; Wilson, AF; George, SC;
Indirizzi:
Univ Calif Irvine, Dept Chem & Biochem Engn & Mat Sci, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 ngn & Mat Sci, Irvine, CA 92697 USA Univ Calif Irvine, Ctr Biomed Engn, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 r Biomed Engn, Irvine, CA 92697 USA Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 , Dept Pediat, Irvine, CA 92697 USA Univ Calif Irvine, Dept Med, Div Pulm & Crit Care, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 m & Crit Care, Irvine, CA 92697 USA Univ Calif Irvine, Gen Clin Res Ctr, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 Clin Res Ctr, Irvine, CA 92697 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 91, anno: 2001,
pagine: 2173 - 2181
SICI:
8750-7587(2001)91:5<2173:FNOEPI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYSTIC-FIBROSIS; EXHALED AIR; REPEATED SPIROMETRY; NASAL CONTRIBUTION; PULMONARY-FUNCTION; ASTHMA; AIRWAYS; HUMANS; EXHALATION; CHILDREN;
Keywords:
diffusing capacity; airways; alveolar;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: George, SC Univ Calif Irvine, Dept Chem & Biochem Engn & Mat Sci, 916 EngnTower, Irvine, CA 92697 USA Univ Calif Irvine 916 Engn Tower Irvine CA USA92697 92697 USA
Citazione:
H.W. Shin et al., "Flow-independent nitric oxide exchange parameters in healthy adults", J APP PHYSL, 91(5), 2001, pp. 2173-2181

Abstract

Currently accepted techniques utilize the plateau concentration of nitric oxide (NO) at a constant exhalation flow rate to characterize NO exchange, which cannot sufficiently distinguish airway and alveolar sources. Using nonlinear least squares regression and a two-compartment model, we recently described a new technique (Tsoukias et al. J Appl Physiol 91: 477-487, 2001), which utilizes a preexpiratory breath hold followed by a decreasing flow rate maneuver, to estimate three flow-independent NO parameters: maximum flux of NO from the airways (J(NO,max), pl/s), diffusing capacity of NO in the airways (D-NO,D-air, pl.s(-1).ppb(-1)), and steady-state alveolar concentration (C-alv,C-ss, ppb). In healthy adults (n = 10), the optimal breath-hold time was 20 s, and the mean (95% intramaneuver, intrasubject, and intrapopulation confidence interval) J(NO,max), D-NO,D-air, and C-alv,C-ss are 640 (26, 20, and 15%) pl/s, 4.2 (168, 87, and 37%) pl.s(-1).ppb(-1), and 2.5 (81, 59, and 21%) ppb, respectively. J(NO,max) can be estimated with the greatest certainty, and the variability of all the parameters within the population of healthy adults is significant. There is no correlation between the flow-independent NO parameters and forced vital capacity or the ratio of forced expiratory volume in 1 s to forced vital capacity. With the use of these parameters, the two-compartment model can accurately predict experimentally measured plateau NO concentrations at a constant flow rate. We conclude that this new technique is simple to perform and can simultaneously characterize airway and alveolar NO exchange in healthy adults with the use of a single breathing maneuver.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:41:18