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Titolo:
Prenatal nicotine affects catecholamine gene expression in newborn rat carotid body and petrosal ganglion
Autore:
Gauda, EB; Cooper, R; Akins, PK; Wu, GM;
Indirizzi:
Johns Hopkins Med Inst, Dept Pediat, Baltimore, MD 21287 USA Johns HopkinsMed Inst Baltimore MD USA 21287 at, Baltimore, MD 21287 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 91, anno: 2001,
pagine: 2157 - 2165
SICI:
8750-7587(2001)91:5<2157:PNACGE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROXYLASE MESSENGER-RNA; INFANT-DEATH-SYNDROME; TYROSINE-HYDROXYLASE; IN-VITRO; METHIONINE-ENKEPHALIN; HYPOXIA; RECEPTORS; DOPAMINE; PREPROENKEPHALIN; RESPONSES;
Keywords:
peripheral arterial chemoreceptors; tyrosine hydroxylase; dopamine beta-hydroxylase; preproenkephalin; control of breathing; sudden infant death syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Gauda, EB Johns Hopkins Univ Hosp, 600 N Wolfe St, Baltimore, MD 21287 USAJohns Hopkins Univ Hosp 600 N Wolfe St Baltimore MD USA 21287 SA
Citazione:
E.B. Gauda et al., "Prenatal nicotine affects catecholamine gene expression in newborn rat carotid body and petrosal ganglion", J APP PHYSL, 91(5), 2001, pp. 2157-2165

Abstract

Nicotine exposure modifies the expression of catecholamine and opioid neurotransmitter systems involved in attenuation of hypoxic chemosensitivity. We used in situ hybridization histochemistry to determine the effect of prenatal and early postnatal nicotine exposure on tyrosine hydroxylase (TH), dopamine beta -hydroxylase (D betaH), preproenkephalin (PPE), and D-2-dopamine receptor mRNA levels in the rat carotid body and petrosal ganglion duringpostnatal development. In the carotid body, nicotine increased TH mRNA expression in animals at 0 and 3 postnatal days (both, P < 0.05 vs. control) without affecting TH mRNA levels at 6 and 15 days. At 15 postnatal days, D<beta>H mRNA levels were increased in the carotid body of nicotine-exposed animals. Dopamine D-2-receptor mRNA levels in the carotid body increased withpostnatal age but were unaffected by nicotine exposure. PPE was not expressed in the carotid body at any of the ages studied in control or treated animals. In the petrosal ganglion, nicotine increased the number of ganglion cells expressing TH mRNA in animals at 3 days (P < 0.01 vs. control). D<beta>H mRNA expression was not induced nor was PPE mRNA expression increased in the petrosal ganglion in treated animals. Prenatal nicotine exposure upregulates mRNAs involved in the synthesis of two inhibitory neuromodulators, dopamine and norepinephrine, in peripheral arterial chemoreceptors, which may contribute to abnormalities in cardiorespiratory control observed in nicotine exposed animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:49:57