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Titolo:
Interleukin-6 response to exercise and high-altitude exposure: influence of alpha-adrenergic blockade
Autore:
Mazzeo, RS; Donovan, D; Fleshner, M; Butterfield, GE; Zamudio, S; Wolfel, EE; Moore, LG;
Indirizzi:
Univ Colorado, Dept Kinesiol & Appl Physiol, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 & Appl Physiol, Boulder, CO 80309 USA Palo Alto Vet Affairs Hlth Care Syst, Palo Alto, CA 94304 USA Palo Alto Vet Affairs Hlth Care Syst Palo Alto CA USA 94304 CA 94304 USA Univ Colorado, Hlth Sci Ctr, Denver, CO 80262 USA Univ Colorado Denver COUSA 80262 ado, Hlth Sci Ctr, Denver, CO 80262 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 91, anno: 2001,
pagine: 2143 - 2149
SICI:
8750-7587(2001)91:5<2143:IRTEAH>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; PLASMA IL-6; BODY-TEMPERATURE; OPEN-FIELD; TNF-ALPHA; CYTOKINES; STRESS; INCREASES; RELEASE; EXPRESSION;
Keywords:
hypoxia; catecholamines; norepinephrine; epinephrine; cytokines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Mazzeo, RS Univ Colorado, Dept Kinesiol & Appl Physiol, Box 354, Boulder, CO 80309 USA Univ Colorado Box 354 Boulder CO USA 80309 oulder, CO 80309 USA
Citazione:
R.S. Mazzeo et al., "Interleukin-6 response to exercise and high-altitude exposure: influence of alpha-adrenergic blockade", J APP PHYSL, 91(5), 2001, pp. 2143-2149

Abstract

Interleukin-6 (IL-6), an important cytokine involved in a number of biological processes, is consistently elevated during periods of stress. The mechanisms responsible for the induction of IL-6 under these conditions remain uncertain. This study examined the effect of alpha -adrenergic blockade on the IL-6 response to acute and chronic high-altitude exposure in women bothat rest and during exercise. Sixteen healthy, eumenorrheic women (aged 23.2 +/- 1.4 yr) participated in the study. Subjects received either a-adrenergic blockade (prazosin, 3 mg/day) or a placebo in a double-blinded, randomized fashion. Subjects participated in submaximal exercise tests at sea level and on days 1 and 12 at altitude (4,300 m). Resting plasma and 24-h urinesamples were collected throughout the duration of the study. At sea level,no differences were found at rest for plasma IL-6 between groups (1.5 +/- 0.2 and 1.2 +/- 0.3 pg/ml for placebo and blocked groups, respectively). Onacute ascent to altitude, IL-6 levels increased significantly in both groups compared with sea-level values (57 and 84% for placebo and blocked groups, respectively). After 12 days of acclimatization, IL-6 levels remained elevated for placebo subjects; however, they returned to sea-level values in the blocked group. alpha -Adrenergic blockade significantly lowered the IL-6 response to exercise both at sea level (46%) and at altitude (42%) compared with placebo. A significant correlation (P = 0.004) between resting IL-6and urinary norepinephrine excretion rates was found over the course of time while at altitude. In conclusion, the results indicate a role for alpha -adrenergic regulation of the IL-6 response to the stress of both short-term moderate-intensity exercise and hypoxia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:18:45