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Titolo:
Chronic administration of therapeutic levels of clenbuterol acts as a repartitioning agent
Autore:
Kearns, CF; McKeever, KH; Malinowski, K; Struck, MB; Abe, T;
Indirizzi:
Rutgers State Univ, Dept Anim Sci, Equine Exercise Physiol Lab, New Brunswick, NJ 08901 USA Rutgers State Univ New Brunswick NJ USA 08901 New Brunswick, NJ 08901 USA Tokyo Metropolitan Univ, Dept Exercise & Sport Sci, Tokyo 1920397, Japan Tokyo Metropolitan Univ Tokyo Japan 1920397 rt Sci, Tokyo 1920397, Japan
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 91, anno: 2001,
pagine: 2064 - 2070
SICI:
8750-7587(2001)91:5<2064:CAOTLO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC RECEPTORS; GROWTH-HORMONE SECRETION; SKELETAL-MUSCLE; EXERCISE PERFORMANCE; TREADMILL EXERCISE; PROTEIN-SYNTHESIS; SENSITIVE LIPASE; BODY-COMPOSITION; ADIPOSE-TISSUE; FIBER TYPE;
Keywords:
ultrasound; equine; beta 2-agonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: McKeever, KH Rutgers State Univ, Dept Anim Sci, Equine Exercise Physiol Lab, 84 Lipman Dr, New Brunswick, NJ 08901 USA Rutgers State Univ 84 Lipman Dr New Brunswick NJ USA 08901 SA
Citazione:
C.F. Kearns et al., "Chronic administration of therapeutic levels of clenbuterol acts as a repartitioning agent", J APP PHYSL, 91(5), 2001, pp. 2064-2070

Abstract

The purpose of this study was to examine the effect of therapeutic levels of clenbuterol, with and without exercise training, on body composition. Twenty-three unfit Standardbred mares were divided into four experimental groups: clenbuterol (2.4 mug/kg body wt twice daily) plus exercise (ClenEx; 20min at 50% maximal oxygen consumption 3days/ wk; n = 6), clenbuterol only (Clen; n = 6), exercise only (Ex; n = 5), and control (Con; n 5 6). Rump fat thickness was measured at 2-wk intervals by using B-mode ultrasound, and percent body fat (% fat) was calculated by using previously published methods. For Ex, body fat decreased (P< 0.05) at week 4 (-9.3%), %fat at week 6 (-6.9%), and fat-free mass (FFM) increased (P< 0.05) at week 8 (+3.2%). On the other hand, Clen had significant changes in %fat (-15.4%), fat mass (-14.7%), and FFM (+4.3%) at week 2. ClenEx had significant decreases in %fat (-17.6%) and fat mass (-19.5%) at week 2, which was similar to Clen; however, this group had a different FFM response, which significantly increased (4.4%) at week 6. Con showed no changes (P> 0.05) in any variable at any time. These results suggest that exercise training and clenbuterol have additive effects with respect to %fat and fat mass but antagonistic effects in terms of FFM. Furthermore, chronic clenbuterol administration causes significant repartitioning in the horse, even when administered in therapeutic doses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:23:11