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Titolo:
Effect of endotoxin on oleic acid lung injury does not depend on priming
Autore:
Schuster, DP; Kozlowski, JK; McCarthy, T; Morrow, J; Stephenson, A;
Indirizzi:
Washington Univ, Sch Med, Div Pulm & Crit Care, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Crit Care, St Louis, MO 63110 USA St Louis Univ, St Louis, MO 63103 USA St Louis Univ St Louis MO USA 63103St Louis Univ, St Louis, MO 63103 USA Vanderbilt Univ, Sch Med, Nashville, TN 37240 USA Vanderbilt Univ Nashville TN USA 37240 , Sch Med, Nashville, TN 37240 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 91, anno: 2001,
pagine: 2047 - 2054
SICI:
8750-7587(2001)91:5<2047:EOEOOA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOXIC PULMONARY VASOCONSTRICTION; PERFUSION REDISTRIBUTION; ARACHIDONIC-ACID; LIPOPOLYSACCHARIDE; ARDS; CYCLO-OXYGENASE-2; THROMBOXANE; EXPRESSION; SYNTHASE-2; INDUCTION;
Keywords:
positron emission tomography; pulmonary edema;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Schuster, DP Washington Univ, Sch Med, Div Pulm & Crit Care, 510 S Kingshighway,Univ Box 8225, St Louis, MO 63110 USA Washington Univ 510 S Kingshighway,Univ Box 8225 St Louis MO USA 63110
Citazione:
D.P. Schuster et al., "Effect of endotoxin on oleic acid lung injury does not depend on priming", J APP PHYSL, 91(5), 2001, pp. 2047-2054

Abstract

Recent studies have demonstrated significant synergistic physiological andbiochemical effects between low-dose endotoxin (Etx) administration and oleic acid (OA)-induced canine lung injury. To evaluate whether this interaction depends on Etx priming of some key cell population, we compared the effects of giving low-dose Etx both after as well as before inducing lung injury with OA. In addition to hemodynamic and blood-gas measurements, positronemission tomographic imaging was used to measure edema accumulation and intrapulmonary blood flow distribution. Biochemical measurements of the stable metabolites of prostacyclin and thromboxane were obtained as well as measurements of isoprostanes and reactive sulfhydryls as evidence for possible concomitant oxidant production. We found that the physiological and biochemical effects of low-dose Etx developed 30-45 min after its administration, regardless of whether Etx was administered before or after OA. No increase in either isoprostane or reactive sulfhydryl production after Etx and/or OAwas detected. These data suggest that the synergistic effect of low-dose Etx and OA-induced lung injury is not due to a priming effect of Etx.

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Documento generato il 28/01/20 alle ore 14:49:35