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Titolo:
NO2 interfacial transfer is reduced by phospholipid monolayers
Autore:
Connor, LM; Bidani, A; Goerke, J; Clements, JA; Postlethwait, EM;
Indirizzi:
Univ Texas, Med Branch, Dept Internal Med, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 t Internal Med, Galveston, TX 77555 USA Univ Calif San Francisco, Cardiovasc Res Inst, Dept Physiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Cardiovasc Res Inst, Dept Pediat, San Francisco,CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco,CA 94143 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 91, anno: 2001,
pagine: 2024 - 2034
SICI:
8750-7587(2001)91:5<2024:NITIRB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL LINING FLUID; NITROGEN-DIOXIDE; REACTIVE ABSORPTION; SURFACTANT PROTEIN; LUNG; MECHANISMS; MODEL; KINETICS; GAS; PHOSPHATIDYLCHOLINES;
Keywords:
nitrogen dioxide; reactive absorption; pulmonary surfactant; interfacial resistance; lung epithelial lining fluid; dipalmitoyl phosphatidylcholine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Postlethwait, EM Univ Texas, Med Branch, Dept Prevent Med & Community Hlth, 301 Univ Blvd, Galveston, TX 77555 USA Univ Texas 301 Univ Blvd GalvestonTX USA 77555 77555 USA
Citazione:
L.M. Connor et al., "NO2 interfacial transfer is reduced by phospholipid monolayers", J APP PHYSL, 91(5), 2001, pp. 2024-2034

Abstract

Nitrogen dioxide (NO2) is a ubiquitous, pollutant gas that produces a broad range of pathological and physiological effects on the lung. Absorption of inhaled NO2 is coupled to near-interfacial reactions between the solute gas and constituents of the airway and alveolar epithelial lining fluid. Although alveolar surfactant imparts limited resistance to respiratory gas exchange compared with that contributed by either the pulmonary membrane or uptake in red blood cells, resistance to NO2 flux could have a significant effect on NO2 absorption kinetics. To investigate the effect of interfacial surfactant on NO2 absorption, we designed an apparatus permitting exposure of variably compressed monolayers. Our results suggest that compressed monolayers enriched in 1,2-dipalmitoyl-sn-3-glycerophosphocholine present significant resistance to NO2 absorption even at surface tensions greater than those achieved in vivo. However, monolayers composed of pure unsaturated phospholipids failed to alter NO2 absorption significantly when compressed, in spite of similar reductions in surface tension. The results demonstrate that phospholipid monolayers appreciably limit NO2 absorption and further thatmonolayer-induced resistance to NO2 flux is related to physicochemical properties of the film itself rather than alterations within the aqueous and gas phases. On the basis of these findings, we propose that pulmonary surfactant may influence the intrapulmonary gas phase distribution of inhaled NO2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:40:32