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Titolo:
Pulmonary arterial dilation by inhaled NO: arterial diameter, NO concentration relationship
Autore:
Bentley, J; Rickaby, D; Haworth, ST; Hanger, CC; Dawson, CA;
Indirizzi:
Zablocki Vet Affairs Med Ctr, Res Serv 151, Milwaukee, WI 53593 USA Zablocki Vet Affairs Med Ctr Milwaukee WI USA 53593 lwaukee, WI 53593 USA Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 hysiol, Milwaukee, WI 53226 USA Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 hesiol, Milwaukee, WI 53226 USA Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53201 USA Marquette Univ Milwaukee WI USA 53201 iomed Engn, Milwaukee, WI 53201 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 91, anno: 2001,
pagine: 1948 - 1954
SICI:
8750-7587(2001)91:5<1948:PADBIN>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; HYPOXIA; VASOCONSTRICTION; LUNG; VASODILATION; VESSELS; BLOOD; TREE; CATS; SITE;
Keywords:
serotonin; pulmonary vascular resistance; pulmonary X-ray angiography; dog lung; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Dawson, CA Zablocki Vet Affairs Med Ctr, Res Serv 151, 5000 W Natl Ave, Milwaukee, WI53593 USA Zablocki Vet Affairs Med Ctr 5000 W Natl Ave MilwaukeeWI USA 53593
Citazione:
J. Bentley et al., "Pulmonary arterial dilation by inhaled NO: arterial diameter, NO concentration relationship", J APP PHYSL, 91(5), 2001, pp. 1948-1954

Abstract

The objective of this study was to determine the nitric oxide (NO) concentration and vessel diameter dependence of the pulmonary arterial dilation induced by inhaled NO. Isolated dog lung lobes were situated between a microfocal X-ray source and X-ray detector and perfused with either blood or plasma. Boluses of radiopaque contrast medium were injected into the lobar artery under control conditions, when the pulmonary arteries were constricted by infusion of serotonin and when the serotonin infusion was accompanied by inhalation of from 30 to 960 parts/million NO. Arterial diameter measurements were obtained from X-ray images of vessels having control diameters in the 300- to 3,400-mum range. Serotonin constricted the vessels throughout the size range studied, with an average decrease in diameter of similar to 20%. The fractional reversal of the serotonin-induced constriction by inhaledNO was directly proportional to inhaled NO concentration, inversely proportional to vessel size, and greater with plasma than with blood perfusion invessels as large as 3 mm in diameter. The latter indicates that intravascular hemoglobin affected the bronchoalveolar-to-arterial luminal NO concentration gradient in fairly large pulmonary arteries. The data provide information regarding pulmonary arterial smooth muscle accessibility to intrapulmonary gas that should be useful as part of the database for modeling the communication between intrapulmonary gas and pulmonary arterial smooth muscle cells in future studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:30:51