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Titolo:
Exchange dynamics of nitric oxide in the human nose
Autore:
Chambers, DC; Carpenter, DA; Ayres, JG;
Indirizzi:
Birmingham Heartlands Hosp, Dept Resp Med, Birmingham B9 5SS, W Midlands, England Birmingham Heartlands Hosp Birmingham W Midlands England B9 5SS , England Univ Oxford, St Hughs Coll, Oxford OX2 6LE, England Univ Oxford Oxford England OX2 6LE t Hughs Coll, Oxford OX2 6LE, England
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 91, anno: 2001,
pagine: 1924 - 1930
SICI:
8750-7587(2001)91:5<1924:EDONOI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER AIRWAY-RESISTANCE; LUNG EPITHELIAL-CELLS; HUMAN NASAL-MUCOSA; SYNTHASE; FLOW; EXPRESSION; HYPOXIA; RELEASE; OXYGEN; SINUSES;
Keywords:
nasal; gas flow; oxygen tension; modeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Ayres, JG Birmingham Heartlands Hosp, Dept Resp Med, Bordesley Green E, Birmingham B9 5SS, W Midlands, England Birmingham Heartlands Hosp Bordesley Green E Birmingham W Midlands England B9 5SS
Citazione:
D.C. Chambers et al., "Exchange dynamics of nitric oxide in the human nose", J APP PHYSL, 91(5), 2001, pp. 1924-1930

Abstract

Nasal nitric oxide (NO) exchange dynamics are poorly understood but potentially are of importance, inasmuch as they may provide insight into the NO-related physiology of the bronchial tree. In healthy human volunteers, NO output was assessed by isolating the nasal cavity through elevation of the soft palate and application of tight-fitting nasal olives. Mean NO output was334 nl/min and was a positive function of gas flow. With the use of a mathematical model and the introduction of nonzero concentrations of NO, the diffusing capacity for NO in the nose (D-NO) and the mucosal NO concentration(C-w) were determined. D-NO ranged from 0.52 to 2.98 x 10(-3) nl.s(-1).ppb(-1) and C-w from 1,236 to 8,947 ppb. C-w declined with increasing gas flow, while DNO was constant. NO output declined with luminal hypoxia, particularly at oxygen tensions <10%. Measurement of nasal DNO and Cw is easy usingthis method, and the range of intersubject values of Cw raises the possibility of interindividual differences in NO-dependent nasal physiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:23:03