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Titolo:
Expression of Notch pathway components in spermatogonia and Sertoli cells of neonatal mice
Autore:
Dirami, G; Ravindranath, N; Achi, MV; Dym, M;
Indirizzi:
Georgetown Univ, Med Ctr, Dept Cell Biol, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 ll Biol, Washington, DC 20007 USA
Titolo Testata:
JOURNAL OF ANDROLOGY
fascicolo: 6, volume: 22, anno: 2001,
pagine: 944 - 952
SICI:
0196-3635(200111/12)22:6<944:EONPCI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL-MESENCHYMAL INTERACTIONS; CAENORHABDITIS-ELEGANS; INTRACELLULAR DOMAIN; IN-VITRO; DELTA; PRESENILIN-1; GENE; DROSOPHILA; RECEPTOR; LIGAND;
Keywords:
cell fate; delta; jagged; presenilin; spermatogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Dym, M Georgetown Univ, Med Ctr, Dept Cell Biol, 3900 Reservoir Rd NW, Washington, DC 20007 USA Georgetown Univ 3900 Reservoir Rd NW Washington DC USA 20007 07 USA
Citazione:
G. Dirami et al., "Expression of Notch pathway components in spermatogonia and Sertoli cells of neonatal mice", J ANDROLOGY, 22(6), 2001, pp. 944-952

Abstract

Members of the Notch gene family have been shown to play an important rolein the control of cell fate in many developmental systems. We hypothesizedthat the fate of the male germ line stem cells may also be mediated through the Notch signaling pathway. We therefore sought to determine whether thecomponents of the Notch pathway are expressed in the mouse testis. Westernblot analysis revealed the expression of three Notch receptors (Notch 1, Notch 2, and Notch 3), Notch ligands (Jagged 1, Jagged 2, and Delta 1), and presenilin 1 (PS1) in neonatal mouse testis. We then examined their cellular localization by immunohistochemical analysis of cocultures of spermatogonia and Sertoli cells. The 3 Notch receptors were found to be expressed in spermatogonia. Sertoli cells expressed only Notch 2 receptor. Among the Notch ligands, Delta 1 and Jagged I were localized exclusively in spermatogoniaand Sertoli cells, respectively. PS1 was apparent in both spermatogonia and Sertoli cells. The presence of Notch receptors and Notch ligands in spermatogonia and Sertoli cells indicates that these cells are capable of responding to and eliciting Notch signaling during the process of spermatogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:50:25