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Titolo:
Latex Aspergillus antigen detection in invasive aspergillosis: Value in a multicenter prospective study
Autore:
Piens, MA; Lebeau, B; Chapuis, F; Thiebaut, A; Nicolle, MC;
Indirizzi:
Fac Med, Lab Parasitol Mycol Med & Pathol Exot, F-69373 Lyon 08, France Fac Med Lyon France 08 Mycol Med & Pathol Exot, F-69373 Lyon 08, France
Titolo Testata:
JOURNAL DE MYCOLOGIE MEDICALE
fascicolo: 2, volume: 11, anno: 2001,
pagine: 61 - 66
SICI:
1156-5233(200106)11:2<61:LAADII>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED-IMMUNOSORBENT-ASSAY; AGGLUTINATION-TEST; IMMUNOCOMPROMISED PATIENTS; DIAGNOSIS; GALACTOMANNAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Piens, MA Fac Med, Lab Parasitol Mycol Med & Pathol Exot, 8 Ave Rockefeller, F-69373Lyon 08, France Fac Med 8 Ave Rockefeller Lyon France 08 F-69373Lyon 08, France
Citazione:
M.A. Piens et al., "Latex Aspergillus antigen detection in invasive aspergillosis: Value in a multicenter prospective study", J MYCOL MED, 11(2), 2001, pp. 61-66

Abstract

Objective. Invasive aspergillosis, a serious disease in immunocompromised patients, remains difficult to diagnose. For this reason, Aspergillus antigen detection has become a promising diagnostic test, The aim of this study was to evaluate Pastorex((R)) Aspergillus antigen latex agglutination test characteristics in invasive filamentous fungal infections on a large population of patients. Patients and methods. An exhaustive, multicenter, prospective and descriptive study was performed in 23 hematology departments in the southeast of France between 1993 and 1996, The detection of Aspergillus antigen in serum was investigated in 182 patients with proven or possible fungal infection. Results. A median of four samples per patient (range 1-31) was taken. For the whole of the 182 patients, the sensitivity of latex agglutination testing was 33 % (60/182 patients) and 40.2 % (41/102 patients) for patients with proven or possible invasive aspergillosis, The antigenemia test became positive with a median of three days after clinical and/or radiological evidence of invasive aspergillosis. Patients with a positive antigenemia test had a poorer outcome than patients who did not have a positive result. Conclusion. The latex Aspergillus antigen test has a number of useful characteristics such as ease-of-use, rapidity and low cost. In spite of its lack of sensitivity, this latex agglutination test remains useful on a routinebasis for all laboratories.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 00:07:06