Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Protective effect of FR183998, a Na+/H+ exchange inhibitor, against postischernic injury after normothermic and prolonged hypothermic ischemia in isolated perfused rat hearts
Autore:
Ohara, F; Yamamoto, N; Maeda, K; Ozaki, T; Seki, J; Goto, T;
Indirizzi:
Fujisawa Pharmaceut Co Ltd, Med Biol Res Labs, Dept Cardiovasc Dis, Osaka 5328514, Japan Fujisawa Pharmaceut Co Ltd Osaka Japan 5328514 Dis, Osaka 5328514, Japan Fujisawa Pharmaceut Co Ltd, Res Planning, Osaka 5328514, Japan Fujisawa Pharmaceut Co Ltd Osaka Japan 5328514 ing, Osaka 5328514, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 87, anno: 2001,
pagine: 110 - 116
SICI:
0021-5198(200110)87:2<110:PEOFAN>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
REDUCES INFARCT SIZE; CARDIAC ISCHEMIA; H+ EXCHANGE; REPERFUSION INJURY; SODIUM; AMILORIDE; RECOVERY; OVERLOAD; HOE-694; CALCIUM;
Keywords:
cardioplegia; FR183998; Na+/H+ exchange; ischemia and reperfusion; hypothermia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ohara, F Fujisawa Pharmaceut Co Ltd, Med Biol Res Labs, Dept Cardiovasc Dis, Osaka 5328514, Japan Fujisawa Pharmaceut Co Ltd Osaka Japan 5328514 a 5328514, Japan
Citazione:
F. Ohara et al., "Protective effect of FR183998, a Na+/H+ exchange inhibitor, against postischernic injury after normothermic and prolonged hypothermic ischemia in isolated perfused rat hearts", JPN J PHARM, 87(2), 2001, pp. 110-116

Abstract

Inhibition of Na+/H+ exchanger has been reported to protect hearts from ischemia and reperfusion injury. However, the effect of Na+/H+ exchange inhibition on hypothermic ischemic injury has not been extensively studied and the results are inconsistent. The purpose of this study was to investigate whether inhibition of Na+/H+ exchange with FR183998 (5-(2,5-dichlorothiphen-3-yl)-3-[(2-dimetliylaminoethyl)carbamoyl]benzoylguanidine dihydrochloride), a potent Na+/H+ exchange inhibitor, would show protective effects againstpostischemic cardiac dysfunction after hypothermic as well as normothermicischemia and furthermore, after hypothermic cardioplegic arrest in isolated rat hearts. FR183998 (3.2 x 10(-8) - 3.2 x 10(-7) M) improved post-ischemic recovery of left ventricular developed pressure and suppressed the increase of left ventricular end diastolic pressure in a dose-dependent manner, after not only 45 min of normothermic ischemia but also 6 h of hypothermic ischemia. Furthermore, FR183998 (10(-7) - 10(-6) M) significantly reduced creatine kinase release during reperfusion after 3 h of hypothermic ischemiawith cardioplegia. These results indicate that FR183998 has a potent protective effect on postischemic cardiac dysfunction after normothermic and hypothermic ischemia, and also on reperfusion injury after hypothermic cardioplegic arrest, suggesting that its effect would be additive to cardioplegia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:44:51