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Titolo:
Expression of WNT10A in human cancer
Autore:
Kirikoshi, H; Inoue, S; Sekihara, H; Katoh, M;
Indirizzi:
Natl Canc Ctr, Res Inst, Genet & Cell Biol Sect, Genet Div,Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Tokyo Japan 1040045 enet Div,Chuo Ku, Tokyo 1040045, Japan Yokohama City Univ, Sch Med, Dept Internal Med 3, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Univ Tokyo, Grad Sch Med, Dept Geriatr Med, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 d, Dept Geriatr Med, Tokyo 1130033, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 5, volume: 19, anno: 2001,
pagine: 997 - 1001
SICI:
1019-6439(200111)19:5<997:EOWIHC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-LINE MCF-7; MOLECULAR-CLONING; GENE FAMILY; CHROMOSOMAL LOCALIZATION; GENOMIC STRUCTURE; ACTIVATION; MUTATIONS; ESTROGEN; MEMBER; DIFFERENTIATION;
Keywords:
WNT; Frizzled; beta-catenin; gastric cancer; pancreatic cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Katoh, M Natl Canc Ctr, Res Inst, Genet & Cell Biol Sect, Genet Div,Chuo Ku, Tsukuiji 5 Chome, Tokyo 1040045, Japan Natl Canc Ctr Tsukuiji 5 Chome Tokyo Japan 1040045 040045, Japan
Citazione:
H. Kirikoshi et al., "Expression of WNT10A in human cancer", INT J ONCOL, 19(5), 2001, pp. 997-1001

Abstract

WNT signaling, pathway is implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized WNT10A, and demonstrated up-regulation of WNT10A in gastric cancer. Here, we investigated expression of WNT10A mRNA in various types of human cancer. WNT10A mRNA was detected in 10 out of 12 esophageal cancer cell lines by cDNA-PCR, and was significantly up-regulated in esophageal cancer cell lines TE2, TE3, TE4, and a brain tumor cell line A-172. WNT10A mRNA was not up-regulated by retinoic acid in a teratocarcinorna cell line NT2. TFF1/pS2 mRNA, but not WNT10A mRNA, was up-regulated by beta -estradiol in a breast cancer cell line MCF-7. Expression of WNT10A mRNA in various types of primary cancers was next investigated byusing Matched tumor/normal expression array fitter. WNT10A mRNA was significantly up-regulated in 2 out of 8 cases of primary gastric cancer, and in 1 out of 7 cases of primary rectal cancer. Expression of WNT10A mRNA in esophageal cancer was not investigated, because. such samples were not blottedon the expression array filter. Up-regulation of WNT10A mRNA might play key roles in some cases of esophageal, gastric, and colorectal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:38:01