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Titolo:
Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2
Autore:
Katoh, M;
Indirizzi:
Natl Canc Ctr, Res Inst,Div Genet, Genet & Cell Biol Sect, Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Tokyo Japan 1040045 ol Sect, Chuo Ku, Tokyo 1040045, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 5, volume: 19, anno: 2001,
pagine: 963 - 969
SICI:
1019-6439(200111)19:5<963:MCGSAE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOMAL LOCALIZATION; BETA-CATENIN; WNT GENE; CANCER; MUTATIONS; HIPPOCALCIN; MEMBER; FAMILY;
Keywords:
WNT; frizzled; beta-catenin; gastric cancer; pancreatic cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Katoh, M Natl Canc Ctr, Res Inst,Div Genet, Genet & Cell Biol Sect, Chuo Ku, Tsukiji 5 Chome, Tokyo 1040045, Japan Natl Canc Ctr Tsukiji 5 Chome Tokyo Japan 1040045 1040045, Japan
Citazione:
M. Katoh, "Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2", INT J ONCOL, 19(5), 2001, pp. 963-969

Abstract

Mouse Nkd is a Dishevel led-binding protein, functioning as a negative regulator of WNT - beta -catenin - TCF signaling pathway. Here, human NKD1 andNKD2 were cloned and characterized. NKD1 and NKD2 were predicted to encode470- and 451-amino-acid polypeptide, respectively. NKD1 and NKD2, showing 43.8% total amino-acid identity, were more homologous in the NH1, NH2, NH3,and NH4 domains. The NH2 domain of NKD1 and NKD2 contained the EF-hand motif. Exon-intron structures of NKD1 and NKD2 genes, consisting of 10 exons, were well conserved. NKD1 was highly expressed in fetal kidney, while NKD2 was moderately expressed in fetal kidney, lung, and adult lung. NKD1 was up-regulated in colorectal cancer cell line SW480, gastric cancer cell line TMK1, and pancreatic cancer cell line Hs700T. NKD2 was up-regulated in gastric cancer cell line MKN45, pancreatic cancer cell line BxPC-3, and esophageal cancer cell lines TE6, and TE13. NKD1 and NKD2 were up-regulated together in I case of primary gastric cancer out of 10 cases, and were down-regulated to-ether in 2 cases. Up-regulation of NKD1 or NKD2 might be due to a negative feed-back mechanism. Alternatively, genetic alteration of NKD1 or NKD2 might lead to activation of the WNT - beta -catenin - TCF signaling pathway.

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Documento generato il 25/09/20 alle ore 22:19:42