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Titolo:
Le(y) glycolipid-recognizing monoclonal antibody inhibits procoagulant activity and metastasis of human adenocarcinoma
Autore:
Inufusa, H; Adachi, T; Kiyokawa, T; Nakatani, Y; Wakano, T; Nakamura, M; Okuno, K; Shiozaki, H; Yamamoto, S; Suzuki, M; Ando, O; Kurimoto, M; Miyake, M; Yasutomi, M;
Indirizzi:
Kinki Univ, Sch Med, Dept Surg 1, Osakasayama, Osaka 5898511, Japan Kinki Univ Osakasayama Osaka Japan 5898511 kasayama, Osaka 5898511, Japan Kinki Univ, Sch Med, Dept Internal Med 2, Osakasayama, Osaka 5898511, Japan Kinki Univ Osakasayama Osaka Japan 5898511 kasayama, Osaka 5898511, Japan Fujisaki Inst, Hayashibara Biochem Labs Inc, Okayama 7028006, Japan Fujisaki Inst Okayama Japan 7028006 hem Labs Inc, Okayama 7028006, Japan Tazuke Kofukai Med Res Inst, Kitano Hosp, Dept Thorac Surg, Kita Ku, Osaka5300026, Japan Tazuke Kofukai Med Res Inst Osaka Japan 5300026 Ku, Osaka5300026, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 5, volume: 19, anno: 2001,
pagine: 941 - 946
SICI:
1019-6439(200111)19:5<941:LGMAIP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER PROCOAGULANT; TUMOR PROCOAGULANT; TISSUE FACTOR; VASCULAR ENDOTHELIUM; CELL-LINES; EXPRESSION; CARCINOMA; ADHESION; COAGULATION; ASSOCIATION;
Keywords:
cancer cell-derived blood-coagulating activity 1; (CCA-1); Le(y) glycolipid; metastasis; tumor procoagulant; nude mouse; human cancer cell line;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Inufusa, H Kinki Univ, Sch Med, Dept Surg 1, 377-2 Ohno Higashi, Osakasayama, Osaka 5898511, Japan Kinki Univ 377-2 Ohno Higashi Osakasayama Osaka Japan 5898511 n
Citazione:
H. Inufusa et al., "Le(y) glycolipid-recognizing monoclonal antibody inhibits procoagulant activity and metastasis of human adenocarcinoma", INT J ONCOL, 19(5), 2001, pp. 941-946

Abstract

Tumor procoagulant is associated with cancer at advanced stages of malignancy such as infiltration and metastasis. In the present study, we investigated the role of Ley glycolipid in the mechanism of cancer metastasis. Ley glycolipid acts as an important cofactor in the expression of the blood-coagulating, activity of cancer cell-derived coagulating activity I (CCA-1), which is one of the known tumor procoagulants. Monoclonal antibody (MoAb) FS01, which serves as the Le(y)-recognizing epitope, inhibits the procoagulantactivity of CCA-1 was found to dose-dependently inhibit the procoagulant activity of normal plasma induced by the human lung, adenocarcinoma cell line, HAL8, which shows a high level of Ley expression. It did not, however, inhibit the procoagulant activity of the human colon cancer cell line, RPMI4788, which does not express Ley. Administration of FS01 MoAb inhibited lungmetastasis of HAL8 cells, but not that of RPMI4788. The absence of antibody-dependent cellular cytotoxicity and complement-mediated cytotoxicity of FS01 MoAb against the HAL8 cell line suggests that the inhibition of HAL8 metastasis by FS01 MoAb derives from the inhibition of blood-coagulating activity of the latter. These findings indicate that Ley glycolipid plays an important role in the mechanism of cancer metastasis via the procoagulant activity of CCA-1.

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Documento generato il 01/04/20 alle ore 16:10:45