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Titolo:
MSH2 and MLH1 immunodetection and the prognosis of colon cancer
Autore:
Perrin, J; Monges, G; Parriaux, D; Noguchi, T; Giovannini, MH; Giovannini, M; Delpero, JR; Birnbaum, D; Monges, G;
Indirizzi:
INSERM U119, F-13009 Marseille, France INSERM U119 Marseille France F-13009 ERM U119, F-13009 Marseille, France Univ Mediterranee, IPC, Dept Mol Oncol, Marseille 9, France Univ Mediterranee Marseille France 9 Dept Mol Oncol, Marseille 9, France Hop Enfants La Timone, Dept Med Informat, Marseille 5, France Hop Enfants La Timone Marseille France 5 d Informat, Marseille 5, France IPC, Dept Biopathol, Marseille, France IPC Marseille FranceIPC, Dept Biopathol, Marseille, France IPC, Dept Med Informat, Marseille, France IPC Marseille FranceIPC, Dept Med Informat, Marseille, France IPC, Dept Oncol Digest, Marseille, France IPC Marseille FranceIPC, Dept Oncol Digest, Marseille, France
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 5, volume: 19, anno: 2001,
pagine: 891 - 895
SICI:
1019-6439(200111)19:5<891:MAMIAT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPLICATION ERROR PHENOTYPE; COLORECTAL-CANCER; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; CLINICOPATHOLOGICAL VARIABLES; INDICATOR; HOMOLOG;
Keywords:
colon cancer; microsatellite instability; immunohistochemistry; repair genes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Birnbaum, D INSERM U119, 27 Bd Lei Roure, F-13009 Marseille, France INSERMU119 27 Bd Lei Roure Marseille France F-13009 , France
Citazione:
J. Perrin et al., "MSH2 and MLH1 immunodetection and the prognosis of colon cancer", INT J ONCOL, 19(5), 2001, pp. 891-895

Abstract

MSH2 and MLH1 are proteins involved in DNA reparation. They are mutated insome forms of colon cancer, i.e. hereditary non-polyposis. carcinomas and a subset of sporadic carcinomas. We have studied the expression of MSH2 andMLH1 in a retrospective series of 225 colorectal carcinomas by immunohistochemistry. The results were compared to molecular tests of microsatellite instability using amplification by PCR of BAT-25 and BAT-26 repeated sequences and to histoclinical data. Positivity of both proteins was never associated with MSI phenotype. MSH2 and/or MLH1 negative tumors were frequently tumors of the proximal colon; in this subpopulation or proximal tumors, MSH2 and/or MLH1 negativity was associated with a longer disease-free survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:20:41