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Titolo:
Effect of a three-amino acid deletion in the alpha(2B)-adrenergic receptorgene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects
Autore:
Sivenius, K; Lindi, V; Niskanen, L; Laakso, M; Uusitupa, M;
Indirizzi:
Univ Kuopio, Dept Clin Nutr, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 lin Nutr, FIN-70211 Kuopio, Finland Univ Kuopio, Dept Med, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Dept Med, FIN-70211 Kuopio, Finland
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 11, volume: 25, anno: 2001,
pagine: 1609 - 1614
SICI:
0307-0565(200111)25:11<1609:EOATAD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL METABOLIC-RATE; SUBTYPE; POLYMORPHISM; PROTEINS; OBESITY; CLONING; FAMILY; GAIN;
Keywords:
alpha(2B)-adrenergic receptor; gene; polymorphism; weight gain; type 2 diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Sivenius, K Univ Kuopio, Dept Clin Nutr, POB 1627, FIN-70211 Kuopio, Finland Univ Kuopio POB 1627 Kuopio Finland FIN-70211 Kuopio, Finland
Citazione:
K. Sivenius et al., "Effect of a three-amino acid deletion in the alpha(2B)-adrenergic receptorgene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects", INT J OBES, 25(11), 2001, pp. 1609-1614

Abstract

BACKGROUND AND OBJECTIVE: The short form (Glu(9)/Glu(9)) of the 12Glu9 deletion polymorphism of the alpha (2B)-adrenergic receptor gene was previously found to be associated with reduced basal metabolic rate in obese subjects. We investigated the effects of this polymorphism on changes in body weight in Finnish non-diabetic and type 2 diabetic subjects during a 10 y follow-up. DESIGN: Controlled 10 y follow-up study with baseline, 5 and 10 y examinations. SUBJECTS: A total of 126 non-diabetic control subjects and 84 newly diagnosed, middle-aged type 2 diabetic patients from eastern Finland participated. MEASUREMENTS: Anthropometric measurements, blood pressure, oral glucose tolerance test, plasma insulin, plasma C-peptide and glycosylated hemoglobin A(1c). Genotypes were determined by polymerase chain reaction followed by agarose gel electrophoresis. RESULTS: No significant differences were found in the prevalence of the 12Glu9 deletion polymorphism between non-diabetic and type 2 diabetic subjects. The non-diabetic subjects with the Glu(9)/Glu(9) genotype had a greater increase in their mean body weight during 5 y follow-up than the non-diabetic subjects with other genotypes (changes in body weight 0.4 5.7, -0.5 6.4 and 3.4 4.9% for the Glu(12)/Glu(12), Glu(12)/Glu(12) and Glu(9)/Glu(9) genotypes, respectively, P = 0.040 for the difference between the groups). Also, the trend for the increment of body weight was statistically significantin the non-diabetic subjects with the Glu(9)/Glu(9) genotype (P = 0.012). The 12Glu9 polymorphism was not cross-sectionally or longitudinally associated with body weight in type 2 diabetic subjects. CONCLUSIONS: The genotype of two short alleles (Glu(9)/Glu(9)) was associated with an increase in body weight among nondiabetic subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:28:15