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Titolo:
Comparison of expression of apoptosis regulatory proteins in the adipose tissue of tumor-bearing and diet-restricted rabbits
Autore:
Ishiko, O; Sumi, T; Yoshida, H; Hyun, Y; Ogita, S;
Indirizzi:
Osaka City Univ, Sch Med, Dept Obstet & Gynecol, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 ecol, Abeno Ku, Osaka 5458585, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 5, volume: 8, anno: 2001,
pagine: 543 - 547
SICI:
1107-3756(200111)8:5<543:COEOAR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANEMIA-INDUCING SUBSTANCE; PROGRAMMED CELL-DEATH; CYCLIC PLASMA PERFUSION; CANCER CACHEXIA; LIPOLYTIC-ACTIVITY; NECROSIS-FACTOR; BCL-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ishiko, O Osaka City Univ, Sch Med, Dept Obstet & Gynecol, Abeno Ku, 1-4-3Asahimachi, Osaka 5458585, Japan Osaka City Univ 1-4-3 Asahimachi Osaka Japan 5458585 585, Japan
Citazione:
O. Ishiko et al., "Comparison of expression of apoptosis regulatory proteins in the adipose tissue of tumor-bearing and diet-restricted rabbits", INT J MOL M, 8(5), 2001, pp. 543-547

Abstract

We investigated the expression of apoptosis regulatory proteins in the adipose tissue of tumor-bearing and diet-restricted rabbits, and analyzed the differences between the two groups. The apoptotic index in the tumor-bearing group was 25.1 12.4 on day 10 and increased to 27.2+/-14.4 by day 20. Thereafter, however, it gradually decreased, falling to 11.2+/-7.8 on day 30 and 0.67+/-0.88 on day 40. By contrast, no apoptotic cells were detected in the diet-restricted group at any of the times examined. Bcl-2 immunoreactivity was either not detected at all, or was only weakly observed in both groups. Bax expression, on the other hand, gradually increased after implantation in the tumor-bearing group. In 2 of the 5 tumor-bearing rabbits, Bax expression in adipocytes was moderate 10 days after tumor implantation, and strong by day 20, but steadily decreased thereafter. By contrast, hardly anyBax-immunopositive cells were detected in the diet-restricted group. Theseresults suggested that loss of body weight in the tumor-bearing,group was different from that in the diet-restricted group, and that it was related to adipocyte apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:43:23