Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats
Autore:
Cancelas, J; Villanueva-Penacarrillo, ML; Valvede, I; Malaisse, WJ;
Indirizzi:
Free Univ Brussels, Expt Med Lab, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 Lab, B-1070 Brussels, Belgium Fdn Jimenez Diaz, E-28040 Madrid, Spain Fdn Jimenez Diaz Madrid Spain E-28040 imenez Diaz, E-28040 Madrid, Spain
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 5, volume: 8, anno: 2001,
pagine: 531 - 532
SICI:
1107-3756(200111)8:5<531:PBGADE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANESTHETIZED RATS; STIMULATION;
Keywords:
glutamic acid dimethyl ester; GLP-1; insulin secretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Malaisse, WJ Free Univ Brussels, Expt Med Lab, 808 Route Lennik, B-1070 Brussels, Belgium Free Univ Brussels 808 Route Lennik Brussels Belgium B-1070
Citazione:
J. Cancelas et al., "Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats", INT J MOL M, 8(5), 2001, pp. 531-532

Abstract

The dimethyl ester of L-glutamic acid (DMG) stimulates insulin release andwas proposed as a possible insulinotropic tool in the treatment of non-insulin-dependent diabetes. In such a perspective, it was investigated whetherDMG enhances the B-cell secretory response to GLP-1 in fed anaesthetized rats. The primed constant infusion of DMG (1.0 mu mol and then 0.5 mu mol/min, both per g body wt.) provoked a rapid and sustained increase in plasma insulin concentration and augmented the release of insulin caused by GLP-1. Thus, DMG indeed appears as a suitable tool to potentiate the insulinotropic action of GLP-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:47:55