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Titolo:
The current status of structural studies on proteins of the myelin sheath (review)
Autore:
Kursula, P;
Indirizzi:
Univ Oulu, Dept Biochem, FIN-90014 Oulu, Finland Univ Oulu Oulu Finland FIN-90014 , Dept Biochem, FIN-90014 Oulu, Finland Univ Oulu, Bioctr Oulu, FIN-90014 Oulu, Finland Univ Oulu Oulu Finland FIN-90014 u, Bioctr Oulu, FIN-90014 Oulu, Finland
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 5, volume: 8, anno: 2001,
pagine: 475 - 479
SICI:
1107-3756(200111)8:5<475:TCSOSS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-NERVE MYELIN; BASIC-PROTEIN; CRYSTAL-STRUCTURE; 3-DIMENSIONAL STRUCTURE; RAT-BRAIN; IMMUNOGLOBULIN SUPERFAMILY; GLYCOPROTEIN MAG; SWISS-MODEL; ADHESION; MEMBRANE;
Keywords:
nervous system; myelin; protein; structure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Kursula, P Univ Oulu, Dept Biochem, POB 3000, FIN-90014 Oulu, Finland UnivOulu POB 3000 Oulu Finland FIN-90014 -90014 Oulu, Finland
Citazione:
P. Kursula, "The current status of structural studies on proteins of the myelin sheath (review)", INT J MOL M, 8(5), 2001, pp. 475-479

Abstract

Myelin, the multilayered membrane structure surrounding axons, provides a unique environment to its proteins, which are either transmembrane proteinsor interacting intimately with the membrane surface. Although myelin-specific proteins have been studied for decades, remarkably little is known of their three-dimensional structures. In addition, the exact functions of myelin proteins are to a large extent unknown. In this report, our current knowledge of peripheral nervous system myelin protein structures is reviewed, and the current status of attempts to solve the structures of full-length myelin proteins is evaluated. Furthermore, molecular models for the extracellular domain of the myelin-associated glycoprotein and the putative kinase-like domain of 2',3'-cyclic nucleotide T-phosphodiesterase are presented anddiscussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:08:37