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Titolo:
Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions
Autore:
Rolfe, KJ; Crow, JC; Benjamin, E; Reid, WMN; Maclean, AB; Perrett, CW;
Indirizzi:
Royal Free & Univ Coll Med Sch, Dept Obstet & Gynecol, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England Royal Free & Univ Coll Med Sch, Dept Histopathol, London, England Royal Free & Univ Coll Med Sch London England topathol, London, England
Titolo Testata:
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
fascicolo: 5, volume: 11, anno: 2001,
pagine: 381 - 386
SICI:
1048-891X(200109/10)11:5<381:CDARPI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; REDUCED EXPRESSION; BLADDER-CANCER; GENE-PRODUCT; LUNG-CANCER; OVEREXPRESSION; PROGNOSIS; PRB; P53; RB;
Keywords:
cell cycle; cyclin D1; immunohistochemistry; retinoblastoma protein; vulvar cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Rolfe, KJ Royal Free & Univ Coll Med Sch, Dept Obstet & Gynecol, Royal Free Campus,Rowland Hill St, London NW3 2PF, England Royal Free & Univ Coll Med Sch Royal Free Campus,Rowland Hill St London England NW3 2PF
Citazione:
K.J. Rolfe et al., "Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions", INT J GYN C, 11(5), 2001, pp. 381-386

Abstract

Abnormalities in the cell cycle are associated with tumorigenesis but havenot yet been identified in squamous cell carcinoma (SCC) of the vulva or in adjacent vulvar lesions. The purpose of this study was to identify cell cycle protein expression (cyclin D1 and retinoblastoma protein [pRb]) in vulvar SCC and in adjacent potentially premalignant lesions: lichen sclerosis (LS), squamous cell hyperplasia (SH), and vulvar intraepithelial neoplasia (VIN). Using immunohistochemical techniques, 57 SCCs were analyzed with 19 adjacent areas showing LS, 13 showing SH, 11 VIN, and six normal epithelium. Fifty-one percent of SCCs showed abnormal cyclin D1 expression and 37% showed abnormal pRb. Abnormal cyclin D1 expression in the adjacent areas was as follows: 53% in LS, 31% in SH, 18% in VIN, and 0% in normal. Abnormal pRb expression was as follows: 42% in LS, 62% in SH, 46% in VIN, and 33% in normal. Only 10 lesions showed abnormal expression of both proteins. Abnormal expression of cyclin D1 in SCC was statistically significant compared with adjacent normal epithelium. In SCC lesions, abnormal cyclin D1 expressionwas associated with greater depth of invasion. Abnormal pRb in SCC was associated with poor tumor grade. Cyclin D1 and pRb are separately involved inthe progression of vulvar cancer, and changes in the expression of these proteins may represent an early stage of malignant transformation in vulvar disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:46:04