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Titolo:
Breast cancer management. 3. Fixed and modifiable risk factors for breast cancer
Autore:
Fentiman, IS;
Indirizzi:
Guys Hosp, Hedley Atkins Breast Unit, London SE1 9RT, England Guys Hosp London England SE1 9RT ns Breast Unit, London SE1 9RT, England
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
fascicolo: 8, volume: 55, anno: 2001,
pagine: 527 - 530
SICI:
1368-5031(200110)55:8<527:BCM3FA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD PROLACTIN LEVELS; TERM FOLLOW-UP; CIGARETTE-SMOKING; RELATIVE WEIGHT; POSTMENOPAUSAL WOMEN; AMERICAN WOMEN; DISEASE; HEIGHT; MENOPAUSE; EPIDEMIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Fentiman, IS Guys Hosp, Hedley Atkins Breast Unit, London SE1 9RT, EnglandGuys Hosp London England SE1 9RT t, London SE1 9RT, England
Citazione:
I.S. Fentiman, "Breast cancer management. 3. Fixed and modifiable risk factors for breast cancer", INT J CL PR, 55(8), 2001, pp. 527-530

Abstract

Likely pathogenesis of breast cancer is in two phases, initiation and promotion. Initiating factors include ionising irradiation, dietary factors andpossibly alcohol consumption causing DNA mutations uncorrected by repair mechanisms. Subsequent promotional factors include exposure to oestrogens, reduced by late menarche, early pregnancy and lactation and increased by nulliparity, oral contraceptive use and hormone replacement therapy. Only 5% of breast cancers result from inherited genetic mutations of BRCA1 and BRCA2, but individuals with such mutations have a high risk (66-80%) of developing the disease. Most patients with benign breast problems are not at increased risk of breast cancer, but those with atypical epithelial hyperplasia have an increased risk and should be kept under surveillance or asked to participate in trials of prevention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:26:55