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Titolo:
The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs)
Autore:
Barr, RK; Bogoyevitch, MA;
Indirizzi:
Univ Western Australia, Dept Biochem, Cell Signallling Lab, Crawley, WA 6009, Australia Univ Western Australia Crawley WA Australia 6009 wley, WA 6009, Australia
Titolo Testata:
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
fascicolo: 11, volume: 33, anno: 2001,
pagine: 1047 - 1063
SICI:
1357-2725(200111)33:11<1047:TCNPKF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERMINAL CENTER KINASE; SIGNAL-TRANSDUCTION PATHWAY; NECROSIS-FACTOR-ALPHA; T-CELL ACTIVATION; NH2-TERMINAL KINASE; GROWTH-FACTOR; MEDIATED APOPTOSIS; MEK KINASE-1; KAPPA-B; LYMPHOCYTE DEVELOPMENT;
Keywords:
protein kinases; scaffolds; signalling pathways; stress-activated MAPKs; JNK MAPKs;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Bogoyevitch, MA Univ Western Australia, Dept Biochem, Cell Signallling Lab, 35 Stirling Highway, Crawley, WA 6009, Australia Univ Western Australia 35 Stirling Highway Crawley WA Australia 6009
Citazione:
R.K. Barr e M.A. Bogoyevitch, "The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs)", INT J BIO C, 33(11), 2001, pp. 1047-1063

Abstract

The c-Jun N-terminal protein kinase mitogen-activated protein kinases (JNKMAPKs) are an evolutionarily-conserved family of serine/threonine protein kinases. First identified in 1990 when intraperitoneal injection of the protein synthesis inhibitor cycloheximide activated a 54 kDa protein kinase, the JNK MAPKs have now taken on a prominent role in signal transduction. This research has revealed a number of levels of complexity. Alternative gene splicing is now recognised to result in ten different JNK MAPK isoforms of 46-55 kDa, and these isoforms differ in their substrate affinities. Furthermore, although originally classified as stress-activated protein kinases (SAPKs), or SAPKs, the JNK MAPKs are also critical mediators of signal transduction in response to stimulation by cytokines and some growth factors, JNKMAPKs have been shown to be critical mediators in dorsal closure in developing Drosophila embryos, and targeted knockout of murine JNK MAPKs has suggested a critical involvement of these kinases in mammalian embryonic development. Recent work has also highlighted their importance in programmed celldeath. Thus, the JNK MAPKs may provide a critical target for regulation inboth normal and diseased states. (C) 2001 Elsevier Science Ltd. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/08/20 alle ore 22:54:54